CAS: 1129-28-8; Methyl 3-(Bromomethyl)Benzoate

相似化合物

6515-58-8 82072-23-9 29333-41-3

上下游产品

3-溴甲基苯甲酸 3-Bromomethylbenzoic Acid 6515-58-8
3-甲基苯甲酸甲酯 1-Methoxycarbonyl-3-Methylbenzene 99-36-5
3-甲醛苯甲酸甲酯 Methyl 3-Formylbenzoate 52178-50-4
3-羟甲基苯甲酸甲酯 Methyl 3-(Hydroxymethyl)Benzoate 67853-03-6
间苯二甲酸单甲酯 Benzene 1,3-Dicarboxylic Acid Monomethyl Ester 1877-71-0
间苯二甲酸二甲酯 Dimethyl Isophthalate 1459-93-4
间甲基苯甲酸 M-Toluic Acid 99-04-7
间苯二甲酸 Isophthalic Acid 121-91-5

3-甲基苯甲酸甲酯置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳 用作溶剂,化学反应 6.0H,以70%的收率获得3-(溴甲基)苯甲酸甲酯
参考文献:用于组装磷酸盐模板化三金属中心的三脚架 Tris-Tacn 和 Tris-Dpa 平台
标题:用于组装磷酸盐模板化三金属中心的三脚架 Tris-Tacn 和 Tris-Dpa 平台
摘要:多齿三足配体 N(Ch2-M-C6H4-Ch2Tacn)3 (L1) 和 N(Ch2-O-C6H4-Ch2N(Ch2Py)2)3 (L2) 已被设计用于组装高核金属簇.通过使用具有不同配体附件(三氮杂环壬烷或二吡啶胺)的相同三足平台,并功能化三(二甲苯基)连接臂上的邻位或间位,制备了与生物学中磷酸盐代谢三金属中心相关的离散三金属磷酸盐单元. 四种这样的化合物,[(Cu(II)Cl)3(Hpo4)L1](Pf6) (1),[(Cu(II)Cl)3(Haso4)L1](Pf6) (2),Na2[mn( Iii)6Mn(II)2(H2O)2(Hpo4)6(Po4)4(L1)2] (3) 和 [co(II)3(H2Po4)Cl2(Mecn)L2](Pf6)3 (4) ),所有金属中心都包含与桥接氧原子的中心磷酸盐或砷酸盐单元结合的三个金属中心,已被合成并在结构上进行了表征.这些结果证明了这种新
Doi:10.1021/ja108212V

专利信息

专利号:US-8058414-B2
优先权日:2008-04-29
标题 :Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
发明人：MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI
权利人:MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI; LIFE TECHNOLOGIES CORP
摘要:Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described.

专利号:US-12129222-B2
优先权日:2016-08-11
标题:Production of bitter principle derivatives
发明人：WYRWA RALF; RODE CLAUDIA; SEEMANN THOMAS; MEINEL LORENZ; RITZER JENNIFER; SCHNABELRAUCH MATTHIAS
权利人:UNIV WUERZBURG J MAXIMILIANS; JULIUS MAXIMILIANS UNIV
摘要:It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1:For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.

专利号:WO-9943409-A1
优先权日:1998-02-27
标 题:Hplc fractionation of complex chemical mixtures
发明人：COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
权利人:ISIS PHARMACEUTICALS INC; COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
摘要:The rapid deconvolution of complex chemical mixtures, such as combinatorial libraries prepared via solution-phase simultaneous addition of functionalities is demonstrated using HPLC. Libraries containing 25-216 members were screened for biological activity and active libraries are fractionated into discreet pools using preferred reversed-phase HPLC. The entire process can be completed from a single synthesis of 15-50 mg, without the need for fixed positions, serial synthesis, or tagging.

专利号:US-6150129-A
优先权日:1996-08-01
标 题 :Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions
发明人：COOK PHILLIP DAN; KAWASAKI ANDREW M; KUNG PEI PEI
权利人:ISIS PHARMACEUTICALS INC
摘要:Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The compounds and compositions of the invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents including employment as species for effecting combinatorial synthesis.

专利号:WO-2022189846-A1
优先权日:2021-03-10
标 题:NOVEL ADENOSYLMERCAPTANE DERIVATIVES AS VIRAL mRNA CAP METHYLTRANSFERASE INHIBITORS
发明人：BOBILEVA OLGA; BOBROVS RAITIS; KANEPE IVETA; KALNINS GINTS; SISOVS MIHAILS; BULA ANNA LINA; JIRGENSONS AIGARS; TARS KASPARS; JAUDZEMS KRISTAPS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to medicine, and in particular to the treatment of viral infections, more particularly to inhibitors of viral mRNA cap methyltransf erases (MTases). Even more particularly, the invention relates to adenosylmercaptane derivatives and pharmaceutical compositions thereof and their use as inhibitors for viral mRNA cap methyltransferases.

专利号:US-2009269759-A1
优先权日:2008-04-29
标题:Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use