CAS: 105250-17-7; (2-Aminopyridin-4-yl)Methanol

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CAS号304873-62-9 2-(B°C-氨基)-4-羟甲基吡啶 | CAS号6937-03-7 2-氨基异烟酸甲酯 | CAS号13362-30-6 2-氨基异烟酸乙酯 | CAS号54221-95-3 2-乙酰基氨基异烟酸 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号5327-32-2 2-(乙酰氨基)-4-甲基吡啶 | CAS号342613-80-3 咪唑并[1,2-a]吡啶-7-甲醇 | CAS号329794-09-4 4-(叔丁基二甲基甲硅烷氧基甲... | CAS号304873-62-9 2-(B°C-氨基)-4-羟甲基吡啶 | CAS号872706-97-3 4-(氯甲基)-2-吡啶胺

4-甲基吡啶-2-甲醛置于叠氮磷酸二苯酯,双氧水,氯,Sodium Carbonate,三乙胺,Manganese(Ll) Chloride,Zinc(II) Chloride体系中,用 水,甲苯 用作溶剂,化学反应 16.0H,反应生成2-氨基吡啶-4-甲醇
参考文献:一种中间体2-氨基吡啶-4-甲醇的制备方法
标题:一种中间体2-氨基吡啶-4-甲醇的制备方法
摘要:本发明公开了一种中间体2‑氨基吡啶‑4‑甲醇的制备方法,包括以下步骤:以4‑甲基吡啶‑2‑甲醛为原料,经氯取代反应,将甲基转化成氯甲基;再进行氧化反应,将醛基转化为羧基,之后与三乙胺和dppa反应,将羧基转化成氨基,最后将氯甲基氧化成为羟甲基,制得2‑氨基吡啶‑4‑甲醇.本申请的制备方法操作简单,条件温和,副产物较少,产物纯度高,产物收率较高.

专利信息

专利号:US-2011166152-A1
优先权日:2008-10-02
标题 :Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.