CAS: 915942-22-2; (E)-N-(4-((3-Chloro-4-(Pyridin-2-Ylmethoxy)Phenyl)Amino)-3-Cyano-7-Ethoxyquinolin-6-yl)-4-(Dimethylamino)But-2-Enamide Maleate

Neratinib Maleate Monohydrate 25.0~50.0 °C,1.33 Kpa 条件下,反应 24.0H,以84%的收率获得产物马来酸来那替尼
参考文献: Maleate Salts Of (E)-N-{4-[3-Chloro-4-(2-Pyridinylmethoxy)Anilino]-3-Cyano-7-Ethoxy-6-Quinolinyl}-4-(Dimethylamino)-2-Butenamide And Crystalline Forms Thereof[fr] Sels Maléates De (E)-N-{4-[3-Chloro-4-(2-Pyridinylméthoxy)Anilino]-3-Cyano-7-éthoxy-6-Quinolinyl}-4-(Diméthylamino)-2-Buténamide Et Leurs Formes Cristallines
标题: Maleate Salts Of (E)-N-{4-[3-Chloro-4-(2-Pyridinylmethoxy)Anilino]-3-Cyano-7-Ethoxy-6-Quinolinyl}-4-(Dimethylamino)-2-Butenamide And Crystalline Forms Thereof[fr] Sels Maléates De (E)-N-{4-[3-Chloro-4-(2-Pyridinylméthoxy)Anilino]-3-Cyano-7-éthoxy-6-Quinolinyl}-4-(Diméthylamino)-2-Buténamide Et Leurs Formes Cristallines

专利信息

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:US-2023391824-A1
优先权日:2021-02-08
标题:Rationale, design, synthesis and validation of a small molecule anticancer agent
发明人：JAIN MOHIT; NARENDRAN ARUMUGAVADIVEL
权利人:NARENDRAN ARUMUGAVADIVEL
摘要:LIN28 is an RNA binding protein that binds and inhibits the expression and maturation of Iet7 microRNA that carries key tumor suppressor functions. Thus, LIN28 is a feasible and effective molecular target for directed inhibition with the potential to provide therapeutic benefit to a diverse group of aggressive malignancies. The present disclosure relates generally to the Rationale, Design, Synthesis and Validation of a Novel Small Molecule Inhibitor of LIN28, coined Compound of formula (I), for the Treatment of Adult and Pediatric Malignancies. In addition, indications of this agent to block cancer metastasis, inhibit cancer stem cells to prevent relapse, and to synergize with immunotherapy, chemotherapy and radiotherapy are also been described.

专利号:US-2024262829-A1
优先权日:2021-04-21
标 题:Peptide nucleic acids, synthesis, and uses thereof
发明人：ROTHMAN JEFFREY
权利人:ONCOGENUITY INC
摘要:The present disclosure provides peptide nucleic acids (PNAs) including cyclic structural moieties such as tetrahydrofuran, pyrrolidinium, pyrrolidine, or N-methyl pyrrolidine, which have surprisingly improved the water solubility and binding affinity of PNA oligomers to ribose-phosphate nucleic acid oligomers. Pharmaceutical compositions including the disclosed PNAs, synthetic methods thereof, and methods of use thereof are also disclosed.

专利号:US-2023160018-A1
优先权日:2020-04-16
标 题 :Crybetab2 predicts poor breast cancer outcome and sensitizes tumors to nucleolin and cdk inhibition
发明人：MERINO VANESSA FERREIRA; POMPER MARTIN; SUKUMAR SARASWATI
权利人:UNIV JOHNS HOPKINS
摘要:CKYPB2 induces EMT, sternness, protein synthesis and cell cycle progression through regulation of nucleolin, con-tributing to an increase in tumor growth and metastasis. CKYPB2 can be used as a prognostic marker in African American women with TNBC. CKYPB2 can further select patients with TNBC and ER positive tumors that will likely benefit from inhibitors of ribosomal RNA synthesis, CDK4 and nucleolin.

专利号:CN-116490201-A
优先权日:2020-07-02
标题 :Inhibitors of YAP/TAZ-TEAD tumor proteins, their synthesis and use