CAS: 7759-35-5; Nestoron

上下游产品

16-Methylene-17α-Hydroxy-17β-Acetyl-19-Norandrosta-4-En-3-One 06/08/7690

反应生成 醋酸烯诺孕酮
参考文献:Synthesewege Zum 17α‐hydroxy‐16‐methylen‐19‐nor‐progesteron Und Seinen Derivaten
标题:Synthesewege Zum 17α‐hydroxy‐16‐methylen‐19‐nor‐progesteron Und Seinen Derivaten
摘要:Abstractverschiedene Synthesewege Zum 17α‐hydroxy‐16‐methylen‐19‐nor‐progesteron (4A) Und Seinen Derivaten Werden Beschrieben. Die C‐19‐funktionalisierung Wird In Jedem Falle über Eine Barton‐reaktion Durchgeführt. Zum Teil Bisher Nicht Beschriebene Nebenprodukte Dieser Reaktion Und Der Folgereaktionen Werden Isoliert Und Aufgeklärt. Sie Gestatten Einen Genaueren Einblick In Die Reaktionsabläufe.
DOI:10.1002/cber.19691020231

专利信息

专利号:WO-2004101594-A1
优先权日:2003-05-14
标题 :New mono-and bismethylene-steroid derivatives and process for their synthesis
发明人：TUBA ZOLTAN; DANCSI LAJOSNE; FRANCSICSNE CZINEGE ERZSEBET; FALKAY GYOERGY; ZUPKO ISTVAN; MARKI ARPAD; MOLNAR CSABA; CSOERGEI JANOS; DUKATNE ABROK VILMA; BALOGH GABOR; MAK MARIANNA
权利人:RICHTER GEDEON VEGYESZET; TUBA ZOLTAN; DANCSI LAJOSNE; FRANCSICSNE CZINEGE ERZSEBET; FALKAY GYOERGY; ZUPKO ISTVAN; MARKI ARPAD; MOLNAR CSABA; CSOERGEI JANOS; DUKATNE ABROK VILMA; BALOGH GABOR; MAK MARIANNA
摘要:The invention relates to new mono- and bismethylene-steroid derivatives of general formula (I) - wherein Z represents two hydrogen atoms or an oxo group; X and Y independently of each other represent either two hydrogen atoms of a CH2= group, with the restriction that at least one of them is CH2= group and if the meaning of Z is oxo group Y represents two hydrogen atoms, R represents a C1-C4 alkyl group, as well as the pharmaceutical compositions containing the above compounds as active ingredients, and the processes for the synthesis of active ingredients and pharmaceutical compositions. The invention also relates to the methods of treatments with these compounds, which means administering to a mammal to be treated with progestogen - including human - effective amount/amounts of the active ingredients of the present invention as such or as medicament. The mono- and bismethylene-steroid derivatives of the general formula (I) have progestogen effect. They can be used as active ingredients of contraceptive medicaments as such or in combination with an estrogen component. Furthermore, they can be used in the treatment of endometriosis and in the substitution therapy of estrogen as gestagen agent beside the estrogen component. The mono- and bismethylene-steroid derivatives of the general formula (I) of the present invention can be synthesized by reacting a compound of the general formula (II), - wherein the meaning of Z, X and Y is as described for the compounds of formula (I) - with an acid anhydride of the general formula (R-CO)2O or with an acid chloride of the general formula R-CO-Cl - wherein R represents a C1-C4 alkyl group - in the presence of a strong acid.