CAS: 76985-08-5; 2-Amino-3-(4-Biphenylyl)Propanoic Acid

上下游产品

p-phenylbenzyl bromide 4-bromo-benzaldehyde phenylboronic acid 4-Phenylbenzaldehyde (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid ([1,1'-biphenyl]-4-yl)alanine (2E)-3-(1,1'-biphenyl-4-yl)acrylic acid methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate

📜Ethyl 3-([1,1'-Biphenyl]-4-yl)-2-Cyanoacrylate置于乙醇,Palladium On Activated Charcoal,水,氢气,Potassium Hydroxide,Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应生成 4-苯基-Dl-苯丙氨酸
参考文献:一种2-氨基-3-联苯基丙酸的制备方法
标题:一种2-氨基-3-联苯基丙酸的制备方法
摘要:本发明公开了一种2‑氨基‑3‑联苯基丙酸的制备方法,步骤如下:步骤1:以对溴苯甲醛和苯硼酸为原料,在碱和催化剂的作用下,以有机溶剂为反应溶剂,进行反应得到联苯基甲醛(II);步骤2:将联苯基甲醛(II)与氰基乙酸乙酯在碱的作用下反应得到中间体(Iii);步骤3:中间体(Iii)在pd/c的催化作用下,在氢气氛围下,与氢气发生还原反应,得到中间体(Iv);步骤4:中间体(Iv)在碱的作用下,在无水乙醇中水解成酰胺化合物(V);步骤5:酰胺化合物(V)与溴素和氢氧化钠的作用下,反应得到2‑氨基‑3‑联苯基丙酸.本方法原材料廉价易得,生产成本低,反应步骤短,反应条件温和,后处理方便,收率高,适合工业化生产.

专利信息

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人：ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-9181175-B2
优先权日:2009-01-13
标 题:Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid
发明人：ZHU GUOLIANG; YANG LIJUN; LIN YING; YING JIE
权利人:ZHU GUOLIANG; YANG LIJUN; LIN YING; YING JIE; ZHEJIANG JIUZHOUS PHARMACEUTICAL CO LTD
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.

专利号:US-7763734-B2
优先权日:2006-04-19
标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis
发明人：WOLF CHRISTIAN; LIU SHUANGLONG
权利人:UNIV GEORGETOWN
摘要:One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.

专利号:US-2025289851-A1
优先权日:2022-04-22
标 题:Cyclic peptides for delivering therapeutics
发明人：DOUGHERTY PATRICK; TOTARO KYLE A; DOMBROSKI AMANDA; GIESLER RILEY; ZHOU MING; STREETER MATTHEW; GOFFIN ALEC; QIAN ZIQING
权利人:ENTRADA THERAPEUTICS INC
摘要:The present disclosure relates to the synthesis of cyclic peptides that are able to effectively deliver cargo, e.g., a therapeutic moiety (TM), inside a cell to treat a variety of conditions and diseases.

专利号:EP-4192512-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates