CAS: 65555-88-6; (S)-2-Amino-3-(4-Methoxyphenyl)-2-Methylpropanoic Acid

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上下游产品

(R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester p-Methoxybenzyl bromide -2-methylpropanedioic acid, dimethyl ester2-(4-methoxyphenyl)methyl-2-methylpropanedioic acid, dimethyl ester acetic acid 3-(4-methoxyphenyl)-2-(4-methoxyphenylazo)-2-methylpropyl esterL-methyltyrosine

合成工艺路线路线简述

  • 合成目标产物 4-Methoxy-A-Methyl-L-Phenylalanine 主要起始原料 4-Methoxybenzyl Bromide
  • (文献来源)合成步骤主要原料 4-Methoxybenzyl Bromide
📜(R)-3-甲氧基-2-(4-甲氧基苄基)-2-甲基-3-氧代丙酸 反应生成 甲基多巴ep杂质b
参考文献:Enzyme Catalysed Hydrolysis Of Dialkylated Propanedioic Acid Diesters Synthesis Of Optically Pure ()-α-Methylphenylalanine,()-α-Methyl-Tyrosine And ()-α-Methyl-3,4-Dihydroxyphenylalanine
标题:Enzyme Catalysed Hydrolysis Of Dialkylated Propanedioic Acid Diesters Synthesis Of Optically Pure ()-α-Methylphenylalanine,()-α-Methyl-Tyrosine And ()-α-Methyl-3,4-Dihydroxyphenylalanine
摘要:
DOI:10.1016/s0040-4039(00)94996-7

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专利信息


专利号:US-2014350284-A1
优先权日:2009-10-30
标题 :Stereoselective synthesis of metyrosine

专利号:US-9452974-B2
优先权日:2009-10-30
标 题 :Stereoselective synthesis of metyrosine
发明人:HALLORAN KEVIN JOHN; COMELY ALEX; CHEN ZHENGMING; KRISHNAN SHYAM
权利人:ATON PHARMA INC
摘要:Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.

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