CAS: 6404-26-8; Boc-Lys(Ac)-Oh

相似化合物

10009-20-8 159766-56-0 76265-69-5

上下游产品

CAS号108-24-7 乙酸酐 | CAS号13734-28-6 B°C-L-赖氨酸 | CAS号692-04-6 Nε-乙酰基-L-赖氨酸 | CAS号13303-10-1 (4-硝基苯基)碳酸叔丁酯 | CAS号1070-19-5 Carbonazidic ac... | CAS号64-19-7 冰醋酸 | CAS号233691-67-3 (S)-(6-乙酰氨基1-((... | CAS号692-04-6 Nε-乙酰基-L-赖氨酸

乙酸酐,N-Alpha-叔丁氧羰基-L-赖氨酸 以 水,乙腈 作为反应溶剂,化学反应生成 N^e-乙酰基-N^a-Boc-L-赖氨酸
参考文献:Inhibitors Selective For Hdac6 In Enzymes And Cells
标题:Inhibitors Selective For Hdac6 In Enzymes And Cells
摘要:Histone Deacetylase Inhibitors With Anticancer Or Anti-Inflammatory Activity Bind To Class I Or Class I And Ii Hdac Enzymes. Here We Compare Selectivity Of Inhibitors Of A Class Ii Hdac Enzyme (Hdac6) And Find One That Retains High Selectivity In Macrophages. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2010.09.100

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.