CAS: 598-22-1; Propionyl Bromide

上下游产品

CAS号79-03-8 丙酰氯 | CAS号16844-98-7 丙酸三甲基硅酯 | CAS号15843-24-0 propan-1-one | CAS号4437-51-8 3,4-己二酮 | CAS号86156-82-3 (1,2-Diethyl-1,... | CAS号19136-92-6 丁酸-D2 | CAS号1461-23-0 三正丁基溴化锡 | CAS号816-40-0 1-溴-2-丁酮 | CAS号563-76-8 2-溴丙酰溴 | CAS号1575-57-1 1-乙酰氧基-2-丁酮 | CAS号1126-56-3 Propanamide,N-c... | CAS号24490-31-1 1-Propanone,1-(... | CAS号92-33-1 1-(10H-吩噻嗪-2-基)丙-1-酮

丙酸置于三溴乙酸乙酯,三苯基膦体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 丙酰溴
参考文献:在无酸条件下与三溴乙酸乙酯/三苯基膦进行温和而有效的将羧酸转化为酰基溴的反应
标题:在无酸条件下与三溴乙酸乙酯/三苯基膦进行温和而有效的将羧酸转化为酰基溴的反应
摘要:在室温下,中性条件下,由羧酸与易得的三溴乙酸乙酯和三苯膦有效地制得酰溴.本方法适用于由芳族和脂族羧酸制备各种酰基溴.发现在反应条件下,芳族羧酸比脂族羧酸更具反应性.
DOI:10.1016/j.Tetlet.2006.06.013

专利信息

专利号:US-2015284338-A1
优先权日:2012-11-21
标 题:Industrial process for the synthesis of pyrimidinyl-piperazine derivatives
发明人：SZAVICSKÓ KRISZTINA; Domány György; Czibula László; Bartáné Szalai Gizella; Dobay László; WERKNÉ PAP ÉVA
权利人:RICHTER GEDEON NYRT
摘要:Our invention relates to trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5,6-dichloro-pyrimidin-2-yl)-methylamine dihydrochloride monohydrate, the process for the synthesis of this compound, the new (4,5-dichloro-6-piperazin-1-yl-pyirimidin-2-yl)-methylamine monohydrochlorid used as starting material in this synthesis, as well as the industrial process for the synthesis of trans-N-(4- {2-[4-(5,6-dichloro-2-methyl-amino-pyirimidin-4-yl-)piperazin-1-yl]-ethly}cyclohexyl-propionamide starting from trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5,6-dichloro-pyrimidin-2-yl)-methylamine dihydrochloride monohydrate.

专利号:US-4239689-A
优先权日:1978-12-18
标题 :Total synthesis of the utero-evacuant substance d,l-zoapatanol
发明人：KANE VINAYAK V
权利人:ORTHO PHARMA CORP
摘要:A method for the synthesis of racemic 2S*, 3R*-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol is described. The naturally occurring product, 2S, 3R-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol, is one of the active components of the zoapatle plant.

专利号:US-3825569-A
优先权日:1967-12-04
标题 :Synthesis of tricyclic carbocyclic compounds and intermediates therefor
发明人：HAJOS Z; OLIVETO E
权利人:HOFFMANN LA ROCHE
摘要:METHODS FOR THE PREPARATION OF 2,3,3A,4,5,7,8,9,9AB,9BADECAHYDRO - 3AB-PRIMARY LOWER ALKYL-7-OXO-1H-BENZ(E) INDENES AND 4,4AB,4BA,5,6,7,8,8A,9,10-DECAHYDRO-8AB-PRIMARY LOWER ALKYL - 3H-PHENANTHREN-2-ONES BY CYCLIZING COMPOUNDS OF THE FORMULA WHERE R1 IS HYDROGEN OR LOWER ALKYL; Z'' IS CARBONYL OR CH(OR2''); R2'' IS HYDROGEN, LOWER AKYL, LOWER ALKANOYL, BENZOYL, NITROBENZOYL, CARBOXY-LOWER ALKANOYL, CARBOXYBENZOYL, TRIFLUOROACETYL OR CAMPHORSULFONYL; T'' IS -C(X'')=CH-, -C(OR3)=CH- OR -Q''-CH2-; R3 IS LOWER ALKYL; X'' IS BROMINE, CHLORINE OR IODINE; Q'' IS CARBONYL, LOWER ALKYLENE DIOXY-METHYLENE, DI-(LOWER ALKOXY)-METHYLENE OR HYDROXY-METHYLENE, R4 IS LOWER PRIMARY ALKYL AND M IS AN INTEGER HAVING A VALUE OF 1 OR 2. THE COMPOUNDS OF THIS SERIES ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF KNOWN STEROIDS WHICH ARE PHARMACOLOGICALLY ACTIVE AS FERTILITY CONTROL AGENTS. CH3)-) R1-CH2-T''-CH2-CH(-CO-H)-CH<(-CH2-(CH2)M-Z''-C(-R4)(-CH2-

专利号:US-8933181-B2
优先权日:2006-10-06
标题:Branched polymers and methods for their synthesis and use
发明人：MOURI HIROSHI; LUO STEVEN; KURASCH JESSICA; ROBERTSON CHRISTOPHER G; WARREN SANDRA
权利人:MOURI HIROSHI; LUO STEVEN; KURASCH JESSICA; ROBERTSON CHRISTOPHER G; WARREN SANDRA; BRIDGESTONE CORP
摘要:Branched polymers including multi-branched polymers, functionalized branched polymers, star-branched polymers, and dendigraft polymers. Methods for the synthesis of branched polymers and method for the use of branched polymers in tire components are also included.

专利号:US-4795813-A
优先权日:1981-08-17
标题 :Synthesis of derivatives of codeine and other 3-O-alkylmorphines
发明人：SCHWARTZ MARTIN A
权利人:UNIV FLORIDA STATE
摘要:A 14-hydroxy group is introduced into a morphinan structure by singlet oxygen reaction with a novel dienol ester of an N-substituted-3-O-alkylnormorphinone. The resultant N-substituted-3-O-alkyl-141-hydroxynormorphinone is also a novel compound which may be catalytically hydrogenated to produce a novel N-substituted-3-O-alkylnoroxymorphone. The latter intermediate may be converted to a 3-O-alkylnoroxymorphone by hydrolytic removal of the N-substituent and to noroxymorphone by both hydrolysis and O-dealkylation. n The dienol ester intermediate is prepared by N-demethylation of codeine or other 3-O-alkylmorphine by reaction with a cyanogen halide or haloformate ester, followed by oxidation of the resultant N-substituted-3-O-alkylnormorphine to an N-substituted-3-O-alkylnormorphinone and esterification of the latter with an acid anhydride or acid halide.

专利号:US-5200514-A
优先权日:1990-01-19
标 题 :Synthesis of 2'-deoxypyrimidine nucleosides
发明人：CHU CHUNG K
权利人:UNIV GEORGIA RES FOUND
摘要:A method for the preparation of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides that includes the step of reacting a nucleoside having hydroxyl groups in the 2' and 3' positions with a mixture of acyl bromide or chloride and HX, wherein X is Br or Cl, at moderate temperature, to give a haloacyl nucleoside derivative that can be deprotected and reduced to form the desired compound.