CAS: 535-87-5; 3,5-Diaminobenzoic Acid

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CAS号99-34-3 3,5-二硝基苯甲酸 | CAS号401-99-0 3,5-二硝基三氟甲苯 | CAS号65-85-0 苯甲酸 | CAS号4277-02-5 3,5-dinitrophth... | CAS号81417-03-0 2.4.5.7-Tetrani... | CAS号7732-18-5 水 | CAS号7647-01-0 盐酸 | CAS号5505-16-8 3,5-二氨基-2,4,6-三碘苯甲酸 | CAS号14266-19-4 methyl 3,5-diio... | CAS号51-36-5 3,5-二氯苯甲酸 | CAS号1949-51-5 3,5-二氨基苯甲酸乙酯 | CAS号248602-44-0 DI-FM°C-3,5-DIA... | CAS号108-45-2 间苯二胺 | CAS号13907-61-4 3,5-bis[(2-chlo... | CAS号136951-59-2 (4-phenylphenyl... | CAS号13908-68-4 Benzoicacid, 3,... | CAS号19094-48-5 3,5-二碘苯甲酸

3,5-二硝基苯甲酸置于锌,Hydrazinium Monoformate体系中,用 水 作为反应溶剂,化学反应 0.07H,以91%的收率获得产物3,5-二氨基苯甲酸
参考文献:Hydrazinium Monoformate:一种新的氢供体.工业锌粉催化选择性还原硝基化合物
标题:Hydrazinium Monoformate:一种新的氢供体.工业锌粉催化选择性还原硝基化合物
摘要:摘要 脂肪族和芳香族硝基化合物中的硝基还含有可还原的取代基,如乙烯,腈,酸,苯酚,卤素,酯等,采用单甲酸肼,在室温下选择性地快速还原为相应的胺,收率非常好,在存在商业锌粉的情况下.据观察,单甲酸肼比肼或甲酸更有效,并且与钯等昂贵金属相比,在低成本锌粉中发生硝基还原而不发生氢解.
DOI:10.1081/scc-120015713

专利信息

专利号:US-4801744-A
优先权日:1985-03-01
标 题 :Catalytic synthesis of urea from carbon monoxide and amine compound
发明人：HERMAN JEAN-JACQUES; LECLOUX ANDRE
权利人:SOLVAY
摘要:Process for the catalytic synthesis of nitrogen-containing organic compounds, comprising the reaction of carbon monoxide with at least one amino compound in a reaction mixture containing a catalyst based on selenium and a substituted pyridine. The process is particularly suitable for the synthesis of ureas and of their polymers.

专利号:US-4515920-A
优先权日:1984-04-30
标题 :Synthesis of peptides and proteins
发明人：ERICKSON BRUCE W
权利人:UNIV ROCKEFELLER
摘要:Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins are synthesized.

专利号:EP-1383732-B1
优先权日:2001-05-04
标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
发明人：BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY
权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT
摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.

专利号:US-7915201-B2
优先权日:2003-03-20
标 题:Ligational encoding of small molecules
发明人：FRANCH THOMAS; JACOBSEN SOEREN NYBOE; RASMUSSEN TORBEN RAVN; NEVE SOEREN; PEDERSEN HENRIK; GOULIAEV ALEX HAAHR
权利人:NUEVOLUTION AS
摘要:The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.