CAS: 5307-05-1; 4-Hydroxy-3-Methylanisol

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📜2-甲基-4-甲氧基苯胺置于硫酸,Sodium Nitrite,Copper(II) Oxide体系中,用47%的收率获得产物2-甲基-4-甲氧基苯酚
参考文献:多臂手性芳基醚构型的组合实验和理论研究
标题:多臂手性芳基醚构型的组合实验和理论研究
摘要:四个系列多臂手性芳基醚上的各种芳核的分子带有两个,三个,五个或八个侧链的(2-5)中制备.通过x射线晶体学分析确定2和3(固态)的结构和构象.而一对交替(抗)构象异构体(即,上下和下向上)的晶体中发现2,在三个侧臂3在相同方向上对齐,得到ç 3-对称顺式构象.通过色散校正的密度泛函(dft-D)计算得出的结果表明,六个反抗构象中的两个和两个2的同构构象异构体中的两个在能量上最重要.通过x射线分析发现,两种计算的抗规整剂结构与固态发现的结构非常吻合.同样,在dft-Db-Lyp / Tzvp级别上优化了syn-3,完全交替4和c 5-对称5的相关构象.该侧臂在结构和构象2-5中溶液温度依赖性的进一步研究1H NMR和紫外可见光谱.此外,进行了对比实验和理论cd光谱研究,以阐明溶液中热力学不稳定的次要异构体的作用.在不同温度下观测到的2和3的cd光谱变化完全不同,而亲本手性芳烃1以及4和5则仅显示1
DOI:10.1021/jo071216N

专利信息

专利号:US-9683015-B2
优先权日:2012-01-03
标 题 :Peptide C alpha-amides, methods for preparing same and uses thereof as precursors of peptide C alpha-thioesters for protein synthesis
发明人：AUCAGNE VINCENT; DELMAS AGNÈS; ADIHOU HÉLÈNE
权利人:CENTRE NAT DE LA RECH SCIENTIFIQUE-CNRS
摘要:The subject matter of the present invention is peptide C α -amides which are precursors of peptide C α -thioesters, characterized in that they comprise the radical of general formula (I) in which X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , n and A are as defined in Claim 1 . The subject matter of the present invention is also the use of these peptide C α -amides for obtaining peptide C α -thioesters. The subject matter of the present invention is also the use of these peptide C α -amides for obtaining peptides or proteins, in particular of therapeutic interest, by direct use as a crypto-thioester partner in NCL reactions.

专利号:CN-118164833-B
优先权日:2024-03-01
标题 :A kind of synthesis method and application of aromatic butanone compounds

专利号:EP-2800756-B1
优先权日:2012-01-03
标题:Peptide c alpha-amides, methods for preparing same and uses thereof as precursors of peptide c alpha-thioesters for protein synthesis

专利号:CN-118164833-A
优先权日:2024-03-01
标题:A kind of synthesis method and application of aromatic butanone compounds