CAS: 497-37-0; Exo-2-Norborneol

该化合物是一种双环二次酒精,具有僵硬分子结构,其特点是其外形结构.该化合物在有机合成中被广泛使用,特别是作为手性建筑块或皮条,在非对称催化中被广泛使用.其严重阻力框架增强了诸如二甲双环添加或氢化等反应的立体选择性. 异丙醇还作为诸如酯类或醚等衍生物的前体,提供稳定性和受控再活性.该化合物的高纯度和定义明确的结构使其对制药,材料科学和芳香化学的研究具有价值. 它的低挥发性和在室内温度下的固态形式有利于在标准实验室条件下的处理和储存.

结构式图片

相似化合物

1632-68-4 497-38-1 36779-79-0

物理性质

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合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-6399776-B2
    优先权日:1994-08-05
    标题:Processes and intermediates in the synthesis of 5-(3-exo-bicyclo[2.2.1]hept-2-yloxy-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidine-2(1H)-one
    发明人：LACOUR THOMAS G; MURTIASHAW III CHARLES WILLIAM
    权利人:PFIZER
    摘要:This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for preparing certain intermediates used in the synthesis of these compounds. It also relates to novel intermediates used in the synthesis of such pharmaceutically active compounds and to other novel compounds that are related to such intermediates.

    专利号:EP-0775119-A1
    优先权日:1994-08-05
    标 题 :Processes and intermediates in the synthesis of 5-(3- exo-bicyclo 2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1h)-one

    专利号:WO-9604253-A1
    优先权日:1994-08-05
    标 题 :Processes and intermediates in the synthesis of 5-(3-[exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1h)-one

    专利号:US-6022968-A
    优先权日:1994-08-05
    标 题:Processes for the synthesis of 5-(3-[exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydr opyrimidin-2(1H)-one

    专利号:US-6274733-B1
    优先权日:1994-08-05
    标 题 :Process and intermediates in the synthesis of 5-(3-[exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydro-pyrimidin-2(1H)-one

    专利号:US-2001041798-A1
    优先权日:1994-08-05
    标题 :Processes and intermediates in the synthesis of 5-(3-{exo-bicyclo{2.2.1}hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6- tetrahydropyrimidin-2(1H)-one

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    合成参考文献


    摘要:Kitching, W.; Glenn, M., Science of Synthesis, (2004) 3, 215.
    摘要:Matteson, D. S., Science of Synthesis, (2005) 6, 23.
    摘要:Margaretha, P., Science of Synthesis, (2007) 35, 68.
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