CAS: 3350-78-5; 3-Methylbut-2-Enoyl Chloride

相似化合物

625-35-4 10487-71-5 107-86-8

上下游产品

4,4-dimethyloxetan-2-one 3-Methylbutenoic acid 4-[(2E)-1-oxo-3-methyl-2-butenyl]morpholine 3,3-dimethyl acrylaldehyde 3-methyl-crotonic acid-(2-dimethylamino-ethyl ester) 1-(2-hydroxy-5-methyl-phenyl)-3-methyl-but-2-en-1-one

3,3-二甲基丙烯酸置于氯化亚砜,Sodium Hydroxide体系中,用 N,N-二甲基乙酰胺,水 作为反应溶剂,化学反应 0.42H,反应生成 3-甲基巴豆酰氯
参考文献:在不存在碱的情况下,使用亚硫酰氯在二甲基乙酰胺中直接由羧酸形成丙烯腈,丙烯酰胺和酰胺
标题:在不存在碱的情况下,使用亚硫酰氯在二甲基乙酰胺中直接由羧酸形成丙烯腈,丙烯酰胺和酰胺
摘要:描述了一种通用的一锅法,该方法可在亚甲基乙酰胺(dmac)中用亚硫酰氯和化学计算量的苯胺依次处理该酸时,将丙烯酸迅速转化为苯胺,产率为88-98%,而dmac提供了速率和稳定性方面的优势.使用dmf.在形成酸酐的过程中,Dmac的使用扩展到了其他有机酸.苄胺酰胺也可以使用化学计量的苄胺形成,并在不存在其他碱的情况下通过加热使其完全.另外,显示了在20oc下添加过量的叔丁胺可以容易地形成叔丁酰胺.
DOI:10.1021/op060125+

专利信息

专利号:US-8507562-B2
优先权日:2004-07-07
标 题 :Synthesis of (1)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and their analogues, intermediates, and composition and uses thereof
发明人：HUANG LAN
权利人:HUANG LAN; HYWE PHARMACEUTICALS INC
摘要:The present invention provides convergent processes for preparing (−)-beta-elemene, (−)-beta-elemenal, (−)-beta-elemenol, and (−)-beta-elemene fluoride and analogues thereof. Also provided are intermediates useful for preparing (−)-beta-elemene. The present invention further provides novel compositions based on analogues of (−)-beta-elemene, (−)-beta-elemenal, (−)-beta-elemenol, (−)-beta-elemene fluoride and methods for the treatment of cancer, such as brain tumor, lung cancer, breast cancer, prostate cancer, ovarian cancer, colorectal cancer, gastric intestional cancer, and stomach cancer. n The inventors propose a combination therapy using 1) one or more of the following anti-cancer agents: including, but not limited to, Cisplatin, 5-FU, Taxol, Taxol derivatives, and any anti-cancer agent, and 2) one or more of the following (−)-beta-elemene and its analogs, including (−)-beta-elemene, (−)-beta-elemenal, (−)-beta-elemenol, (−)-beta-elemene fluoride, and their analogs, and (−)-beta-elemene's intermediate in its chemical synthesis, for the treatment of cancer, especially for the treatment of brain tumor, lung cancer, ovarian cancer, bladder cancer, cervical cancer, colon cancer, breast cancer, and prostate cancer.

专利号:US-2006014987-A1
优先权日:2003-07-07
标 题:Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof
发明人：HUANG LAN
权利人:HUANG LAN
摘要:The present invention provides convergent processes for preparing beta-elemene, and analogues thereof. Also provided are analogues related to beta-elemene and intermediates useful for preparing the same. The present invention further provides novel compositions based on analogues of beta-elemene and methods for the treatment of cancer, such as brain tumor, lung cancer, colorectal cancer, gastric intestional cancer, and stomach cancer.

专利号:US-6908942-B2
优先权日:2002-06-17
标题 :6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives and their construction by parallel synthesis on solid-phase
发明人：GONG YOUNG-DAE; SEO JIN-SOO; HWANG JONG YEON; YOO SUNG-EUN
权利人:KOREA RES INST CHEM TECH
摘要:The present invention provides (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing benzopyran derivatives with high efficiency by parallel synthesis on a solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products.

专利号:US-2007275953-A1
优先权日:2003-09-22
标题:2-Pyridinone Derivatives, Having Hiv Inhibiting Properties
发明人：LE VAN KIET; GEORGES RENOIT; HEYESI LASZLO; CAUVIN CHRISTINE; BOLAND SANDRA; DURANT FRANCOIS; DEMONTE DOMINIQUE; VAN LINT CHRIS; BURNY ARTHU; BOLLEN ALEX; JACQUET ALAIN; DE WALQUE STEPHAINE
权利人:UNIV NOTRE DAME DE LA PAIX; UNIV BRUXELLES
摘要:The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in the treatment of Acquired Immune Deficiency Syndrome (AIDS). The present invention further relates to the synthesis of said compounds and their use, with or without other pharmaceutical agents, in the treatment of AIDS and viral infections by HIV-1.

专利号:US-2007135526-A1
优先权日:2004-07-07
标 题 :Synthesis of (1)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and their analogues, intermediates, and composition and uses thereof

专利号:DE-1921012-A1
优先权日:1968-04-29
标题:Process for the synthesis of antibacterial substances