CAS: 298-55-5; Clocinizine
- 英文名称Clocinizine
- 中文名称氯西尼嗪
- IUPAC名称1-((4-chlorophenyl)(phenyl)methyl)-4-(3-phenylallyl)piperazine
- 其它别名Clocinizine; Clocinizine-D8; 1-[(4-Chloropheny)Phenylmethyl]-4-Cinnamylpiperazine; 1-[(4-Chlorophenyl)Phenylmethyl]-4-Cinnamylpiperazine; Cliocinizine; 1-(4-Chlor-Alpha-Phenylbenzyl)-4-Cinnamylpiperazin; Chlorcinnarizine; Chlorcinnazine
- CAS编号298-55-5
- MFCD编号:MFCD00865653
- FDA UNII编号:8HQJ711KH8
- 分子式:C26H27ClN2分子量:402.97
- 产品CID: 1280552
- 同类组份化合物CAS298-55-5 (free base)39245-23-3 (HCl)
- 产品分类有机原料 → 苯类化合物 → 苯取代衍生物
物理性质
MSDS等安全信息
上下游产品
CAS号303-26-4 1-(4-氯二苯基)哌嗪 | CAS号4392-24-9 肉桂基溴 | CAS号119-56-2 4-氯二苯甲醇 | CAS号134-83-8 4-氯二苯氯甲烷 | CAS号134-85-0 4-氯二苯甲酮合成工艺路线路线简述
📜4-氯二苯氯甲烷置于四丁基碘化铵,Potassium Carbonate,Sodium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 10.25H,反应生成氯西尼嗪
参考文献:Efficient Synthesis Of Antihistamines Clocinizine And Chlorcyclizine
标题:Efficient Synthesis Of Antihistamines Clocinizine And Chlorcyclizine
摘要:A Simple And Efficient Route Has Been Developed For The Synthesis Of Anti-Histamine Drugs Clocinizine And Chlorcyclizine. The Common Intermediate 1-[(4-Chloro Phenyl) (Phenyl)-Methyl]-Piperazine (8),Is Prepared From (4-Chlorophenyl) (Phenyl)-Methanone (5),In Three Steps With Excellent Yields. All The Reactions Proceeded Smoothly And The Products Were Also Isolated Easily.
Doi:10.1007/s00044-011-9556-X
海关参考信息
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2901220000-丙烯
2902300000-甲苯
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主要参考文献
1: Nowacka-Krukowska H, Rakowska M, Neubart K, Kobylińska M. High-performance liquid chromatographic assay for cinnarizine in human plasma. Acta Pol Pharm. 2007 Sep-Oct;64(5):407-11. 59(1):9-14.
合成参考文献
摘要:Nowacka-Krukowska H, Rakowska M, Neubart K, Kobylińska M. High-performance liquid chromatographic assay for cinnarizine in human plasma. Acta Pol Pharm. 2007 Sep;64(5):407–11.
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