专利号:US-2022233673-A1 优先权日:2019-06-04 标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF 发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M 权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND 摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
专利号:WO-2024222981-A1 优先权日:2023-04-28 标题 :Ester conjugate of sphingolipid and hyaluronan, method of synthesis thereof, composition containing thereof, use of conjugate or composition 发明人:JUHASCIK MARTIN; HUERTA-ANGELES GLORIA; STARMANOVA KATERINA; STEPAN PETR; EXNEROVA ANDREA; NESPOROVA KRISTINA; KOVACIK ANDREJ; BRANDEJSOVA MARTINA; VECEROVA PETRA; POLASKOVA JANA; HERMANNOVA MARTINA; BUFFA RADOVAN; VAGNEROVA HANA; VELEBNY VLADIMIR 权利人:CONTIPRO AS 摘要:The present invention relates to an ester conjugate of sphingolipid and hyaluronan, a composition comprising thereof and its use. Furthermore, it relates to methods of the ester conjugate synthesis.
专利号:WO-2024097744-A2 优先权日:2022-11-01 标题 :Dna-compatible wittig olefination of on-dna peptidyl-ylides for development of on-dna peptidomimetics through diversity-oriented synthesis (dos)
专利号:CN-117843715-A 优先权日:2023-12-15 标题 :Liquid phase synthesis method of melanoputan-II
[参考文献]: Suk Hyun Jung, Et Al. Gd(Iii)-Dota-Modified Sonosensitive Liposomes For Ultrasound-Triggered Release And Mr Imaging. Nanoscale Res Lett. 2012 Aug 17;7(1):462.
合成参考文献
参考文献:10.1007/s10967-024-09355-3 摘要:Al-Qahtani M. Full automation of the radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on the ALL IN ONE synthesizer. J Radioanal Nucl Chem. 2024 Feb 12;333(7):3459–68. doi: 10.1007/s10967-024-09355-3.