CAS: 265651-18-1; N,N,N',N'-Tetramethyl-O-(N-Succinimidyl)Uronium Hexafluorophosphate

该化合物是一种混合试剂,广泛用于peptide合成和其他有机反应.其特点是能够激活氨基磺酸,以形成氨基酸为原料,便利于在peptide合成中结合氨基酸.化合物一般是白色到白色的固体,在二甲基甲基甲基胺(DMF)和二甲基硫氧化(DMSO)等极有机溶剂中溶解.HATU以其效率和温和反应条件著称,最大限度地减少侧反应并提高产量.HATU在标准实验室条件下也有利于其稳定性,尽管由于反应活跃性和潜在毒性,应当加以谨慎处理.由于存在氨基基基化合物,可以与氨基化合物有选择性地反应,因此它是合成复杂的有机分子的一种宝贵工具.建议将其适当储存在远离水分的冷干地方,以便保持其完整性和有效性.

结构式图片

相似化合物

105832-38-0 18342-66-0 943858-70-6

欧盟法规

C&L通报

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-2022233673-A1
    优先权日:2019-06-04
    标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
    权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
    摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

    专利号:WO-2024222981-A1
    优先权日:2023-04-28
    标题 :Ester conjugate of sphingolipid and hyaluronan, method of synthesis thereof, composition containing thereof, use of conjugate or composition
    发明人:JUHASCIK MARTIN; HUERTA-ANGELES GLORIA; STARMANOVA KATERINA; STEPAN PETR; EXNEROVA ANDREA; NESPOROVA KRISTINA; KOVACIK ANDREJ; BRANDEJSOVA MARTINA; VECEROVA PETRA; POLASKOVA JANA; HERMANNOVA MARTINA; BUFFA RADOVAN; VAGNEROVA HANA; VELEBNY VLADIMIR
    权利人:CONTIPRO AS
    摘要:The present invention relates to an ester conjugate of sphingolipid and hyaluronan, a composition comprising thereof and its use. Furthermore, it relates to methods of the ester conjugate synthesis.

    专利号:WO-2024097744-A2
    优先权日:2022-11-01
    标题 :Dna-compatible wittig olefination of on-dna peptidyl-ylides for development of on-dna peptidomimetics through diversity-oriented synthesis (dos)

    专利号:CN-117843715-A
    优先权日:2023-12-15
    标题 :Liquid phase synthesis method of melanoputan-II

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Suk Hyun Jung, Et Al. Gd(Iii)-Dota-Modified Sonosensitive Liposomes For Ultrasound-Triggered Release And Mr Imaging. Nanoscale Res Lett. 2012 Aug 17;7(1):462.

    合成参考文献


    参考文献:10.1007/s10967-024-09355-3
    摘要:Al-Qahtani M. Full automation of the radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on the ALL IN ONE synthesizer. J Radioanal Nucl Chem. 2024 Feb 12;333(7):3459–68. doi: 10.1007/s10967-024-09355-3.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知