专利号:US-8735586-B2 优先权日:2007-06-26 标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR 权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:EP-2173747-B1 优先权日:2007-06-26 标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS 权利人:SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:US-8709129-B2 优先权日:2009-07-21 标题 :Compounds useful as ligands of actinides, their synthesis and their uses 发明人:MARIE CÉCILE; MIGUIRDITCHIAN MANUEL; BISSON JULIA; GUILLANEUX DENIS; DUBREUIL DIDIER 权利人:MARIE CÉCILE; MIGUIRDITCHIAN MANUEL; BISSON JULIA; GUILLANEUX DENIS; DUBREUIL DIDIER; COMMISSARIAT ENERGIE ATOMIQUE 摘要:The invention relates to novel compounds which are useful as ligands of actinides, to the synthesis of these compounds and to their uses. n These compounds fit the general formula (I) hereafter: n nwherein R 1 and R 2 , either identical or different, represent H, a linear or branched, saturated or unsaturated C 1 -C 12 hydrocarbon group, a phenyl, benzyl, diphenyl or tolyl group; R 3 represents H, a linear or branched, saturated or unsaturated C 1 -C 12 hydrocarbon group, a phenyl, tolyl or linear or branched C 1 -C 12 alkoxy group; while R 4 represents H, a linear or branched, saturated or unsaturated C 1 -C 12 hydrocarbon group, a phenyl or tolyl group.n n Field of applications: the processing of used nuclear fuels via a hydrometallurgical route.
专利号:US-2011263540-A1 优先权日:2008-07-25 标题 :Small-molecule inhibitors of protein synthesis inactivating toxins 发明人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.
专利号:US-2010261909-A1 优先权日:2007-06-26 标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:WO-2009000413-A1 优先权日:2007-06-26 标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
[参考文献]: Arnau Garau, Et Al. High-Throughput Automatic Flow Method For Determination Of Trace Concentrations Of Aluminum In Dialysis Concentrate Solutions Using Salicylaldehyde Picolinoylhydrazone As A Turn-On Fluorescent Probe. Talanta. 2015 Feb:133:120-6.
合成参考文献
摘要:Wu, S.; Song, H.; Hu, M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 113.