📜2-羟基-4-甲氧基-6-甲基苯甲酸乙酯置于三溴化硼体系中,用 二氯甲烷 用作溶剂,化学反应 0.17H,反应生成2,4-二羟基-6-甲基甲酸乙酯 参考文献:Nematocidal Principles In "Oakmoss Absolute" And Nematocidal Activity Of 2,4-Dihydroxybenzoates 标题:Nematocidal Principles In "Oakmoss Absolute" And Nematocidal Activity Of 2,4-Dihydroxybenzoates 摘要:从橡树苔中提取的杀线虫物质被鉴定为 2,4-二羟基-3,6-二甲基苯甲酸甲酯(2),3-醛基-2,4-二羟基-6-甲基苯甲酸乙酯(4)和 5-氯-3-醛基-2,4-二羟基-6-甲基苯甲酸乙酯(7).根据它们的结构,测试了甲基至十四烷基的 2,4-二羟基苯甲酸酯的杀线虫活性,发现辛酯的活性最强(最小致死浓度=13 μm). Doi:10.1248/cpb.39.1043
专利号:US-8481519-B2 优先权日:2005-02-05 标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy 发明人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA 权利人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA; LOHMANN THERAPIE SYST LTS 摘要:A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.
专利号:US-6900340-B2 优先权日:2001-02-02 标 题:Preparation of isocoumarin derivatives and intermediates for the synthesis thereof 发明人:NAKATA MASAYA 权利人:MERCIAN CORP 摘要:A method of preparing optically active isocoumarin-3-yl-acetic acid derivatives represented by Formula (I): n n nwherein a specific isocoumarin-ketene derivative is subjected to an addition reaction with an optically active alcohol, and then the ester thus obtained is subjected to a hydrolysis reaction. An intermediate for synthesis used therein. A method of preparing isocoumarin-3-yl-acetic acid derivatives represented by Formula (III): n n nwherein a specific isocoumarin derivative is subjected to an addition reaction with carbon monoxide and oxygen in the presence of a transition metal catalyst. An intermediate for synthesis used therein.
专利号:US-2009143466-A1 优先权日:2005-02-05 标题 :Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy
专利号:CA-2596634-C 优先权日:2005-02-05 标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy
专利号:ZA-200706107-B 优先权日:2005-02-05 标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostate hyperplasia, prostate carcinoma, and spinobulbar muscular atrophy
专利号:JP-2008528648-A 优先权日:2005-02-05 标 题:Isolation of atralic acid, synthesis of atralic acid derivatives, and use of atralic acid and its derivatives for the treatment of benign prostatic hyperplasia, prostate malignancies and bulbar spinal muscular atrophy