CAS: 23474-98-8; 2-Amino-5-Chlorobenzenethiol

该化合物是一种稳定的硫醇衍生物,用作有机合成和制药应用的中间体.水含量(~50% w/w)通过减少处理和储存过程中的易燃性和氧化风险而提高安全性.该化合物具有氨基和硫醇两种功能组的特点,在结合,凝聚和金属复合反应中能够多功能性反应.其氯化芳香环进一步有助于其用于建造环流框架或功能化苯.湿状形式确保了稳定性的改善,尽量减少了脱硫化物的形成和降解.对于受控制的环境来说,它通常用于精细的化学和农用化学合成.建议在惰性条件下妥善储存以保持完整性.

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物理性质

MSDS等安全信息

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合成工艺路线路线简述

    📜4-氯苯基硫脲置于氯仿,溴体系中,化学反应生成2-氨基-5-氯噻吩
    参考文献:Synthesis Of Bioactive Substituted Pyrazolylbenzothiazinones
    标题:Synthesis Of Bioactive Substituted Pyrazolylbenzothiazinones
    摘要:吡唑基苯并噻二嗪酮通过在乙醇存在下2-肼基羰甲基-3,4-二氢-2H-1,4-苯并噻二嗪-3-酮与β-二酮的反应合成,产率非常好.通过其分析和光谱数据确定了合成吡唑基苯并噻二嗪酮的结构.合成化合物的抗菌活性也已包含在内.
    Doi:10.1007/s11164-014-1727-1

    海关参考信息

    专利信息


    专利号:US-4975449-A
    优先权日:1983-02-04
    标 题 :Topical treatment of glaucoma with 2-benzothiazolesulfonamide derivative
    发明人：SCHOENWALD RONALD D; BARFKNECHT CHARLES F
    权利人:UNIV IOWA RES FOUND
    摘要:A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-chloro-benzothiazole-2-sulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-chloro-benzothiazole-2-sulfonamide compound.

    专利号:US-3726889-A
    优先权日:1971-01-28
    标题:Synthesis of 2,2'-iminobis(benzothiazoles)
    发明人：D AMICO J
    权利人:MONSANTO CO
    摘要:2,2''-IMINOBIS(BENZOTHIAZOLES) OF THE FORMULA (X-BENZOTHIAZOL-2-YL)2-NH WHEREIN X IS HYDROGEN, ALKYL, ALKOXY, NITRO, HALO OR HYDROXY ARE PREPARED BY REACTING A 2-AMINOBENZENTHIOL WITH S,S''-DI-(LOWER ALKYL)CYANOIMIDODITHIOCARBONATE.

    专利号:NL-9100854-A
    优先权日:1990-05-17
    标 题 :METHOD FOR PREPARING INTERMEDIATES USE FOR THE SYNTHESIS OF BENZODIAZEPINES.

    专利号:CN-111187233-B
    优先权日:2020-01-18
    标 题:A kind of multi-substituted benzothiazole and its derivatives and its synthesis method

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    合成参考文献


    摘要:Wilkins, D. J.; Bradley, P. A., Science of Synthesis, (2004) 13, 268.
    摘要:Argyropoulos, N. G., Science of Synthesis, (2004) 13, 19.
    摘要:Ulrich, H., Science of Synthesis, (2004) 17, 131.
    摘要:Rakitin, O. A., Science of Synthesis, (2007) 31, 966.
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