CAS: 216019-28-2; 3-Isopropylphenylboronic Acid

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CAS号5419-55-6 硼酸三异丙酯 | CAS号5433-01-2 3-溴异丙苯

1-溴-3-异丙基苯置于正丁基锂,硼酸三异丙酯,盐酸体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 4.0H,以1.36 G的收率获得3-异丙基苯硼酸
参考文献:单一邻位取代基在联苯中的旋转
标题:单一邻位取代基在联苯中的旋转
摘要:通过动态NMR光谱法测定了一系列带有单个邻位取代基的联苯化合物1A-1H和2A-2D的旋转障碍,范围高达15.4 Kcal Mol-1.从头算就可以令人满意地重现这些障碍,并表明这些分子的基态构象.根据各个取代基对屏障的贡献以及苯环上相邻位置被取代基支撑的结果讨论了结果.
Doi:10.1021/jo060205B

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-2009306392-A1
优先权日:2007-10-19
标题 :Gsm intermediates
发明人：HO CHIH YUNG
权利人:HO CHIH YUNG
摘要:The present invention relates the use of compounds having the general Formula I, wherein the definitions or R 1 and R 2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of γ-secretase modulators, which are in turn useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.

专利号:US-11795162-B2
优先权日:2017-08-18
标题:Modulators of the estrogen-related receptor
发明人：BURRIS THOMAS; WALKER JOHN K; HAMPTON CARISSA S; HAYNES KEITH MCCORMICK; GRIFFETT KRISTINE; BILLON CYRIELLE; SITAULA SADICHHA
权利人:UNIV SAINT LOUIS
摘要:In one aspect, the present disclosure describes new estrogen receptor-related orphan receptor (EER) inverse agonist compounds. Also described are pharmaceutical formulations, methods of synthesis and uses thereof.

专利号:US-6872745-B2
优先权日:2000-04-14
标 题 :Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：JOHNSON JR THEODORE O; HUA YE; LUU HIEP T; DRAGOVICH PETER S
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.