CAS: 19210-12-9; (1S,4As,5R,7S,7As)-4A,5-Dihydroxy-7-Methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-1,4A,5,6,7,7A-Hexahydrocyclopenta[c]Pyran-7-Yl Cinnamate
该化合物是主要从Harpagophytum procentbens(魔鬼的爪子) 提取的生物活性类固醇胶质, 被广泛研究其潜在的抗炎和止痛特性, 使其成为肌肉骨骼和共同健康研究的关键化合物. Harpagoside 展示了对如COX-2 和 cytokines 等阻燃性调解器的抑制作用, 有助于其治疗潜力. 它的行动机制包括调制NF-XXB 信号路径. 化合物的特点是高度纯度和稳定性, 确保药理学和生物化学应用的可靠性. 包括HPLC 在内的分析方法被用来验证其质量, 使其适合标准化的研发.
- 英文名称(1S,4As,5R,7S,7As)-4A,5-Dihydroxy-7-Methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-1,4A,5,6,7,7A-Hexahydrocyclopenta[c]Pyran-7-Yl Cinnamate
- 中文名称哈巴俄苷
- IUPAC名称(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamate
- 其它别名[(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydr°Cyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate
- CAS编号19210-12-9
- MFCD编号:MFCD00017415
- EINECS号:242-881-6
- FDA UNII编号:8KGS1DC5ZU
- 分子式:C24H30O11分子量:494.49
- 产品CID: 972630
- 产品分类生物化工 → 提取物
物理性质
- 熔点120 °C (分解)
- 沸点720.7±60.0 °C at 760 mmHg
- 闪点244.3±26.4 °C
- 密度1.5±0.1 g/cm3
- pKa:11.70±0.70(预测)
- PSA:175.37
- LogP:-0.92
- 折射率1.660
- 蒸汽压0.0±2.4 mmHg at 25°C
- 溶解性Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
- 外观形态白色至淡黄色固体
- 储存条件惰性气氛,2-8°C
- 产品应用该化合物用作内容确定,识别和药理研究;展览药理效应,包括促进缺血小鼠的淋巴细胞全膜扩散,引入IL-2生产,降低血浆浓度-AMP水平以及使CAMP/CGMP比率正常化以恢复抑制的免疫功能.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号140-10-3 肉桂酸 | CAS号1346708-23-3 H-harpagide合成工艺路线路线简述
专利信息
专利号:US-6280737-B1
优先权日:1996-03-21
标 题 :Harpagoside-enriched extract from harpagophytum procumbens and processes for producing same
发明人：STUMPF KARL-HEINZ; JAGGY HERMANN; OSCHMANN RAINER; KOCH EGON; SIMMET THOMAS
权利人:SCHWABE WILLMAR GMBH & CO
摘要:The disclosure relates to extracts from Harpagophytum procumbens with a high harpagoside content, to processes for producing them, such extracts containing no components capable of stimulating the synthesis of thromboxane B2 and cysteinylleucotrienes, and to pharmaceutical compositions containing such extracts.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Cheng J, Di LQ, Shan JJ, Zhao XL, Kang A, Bi XL, Li JS. [Studies on effects of Achyranthes bidentata on tongsaimai pellets main active ingredients chlorogenic acid, isoliquiritin, harpagoside and glycyrrhizin in vivo pharmacokinetics]. Zhongguo Zhong Yao Za Zhi. 2014 Apr;39(8):1502-8. Chinese.
合成参考文献
参考文献:10.1111/j.2042-7158.2010.01235.x
摘要:Modarai M, Suter A, Kortenkamp A, Heinrich M. The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. J Pharm Pharmacol. 2011 Mar;63(3):429–38. doi: 10.1111/j.2042-7158.2010.01235.x.
参考文献:10.1016/j.bmc.2011.06.069
摘要:Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19(16):4882–6. doi: 10.1016/j.bmc.2011.06.069.
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