CAS: 1898283-02-7; 2-(4-((4-((1-Cyclopropyl-3-(Tetrahydro-2H-Pyran-4-yl)-1H-Pyrazol-4-yl)Oxy)Pyridin-2-yl)Amino)Pyridin-2-yl)Propan-2-Ol
- 英文名称2-(4-((4-((1-Cyclopropyl-3-(Tetrahydro-2H-Pyran-4-yl)-1H-Pyrazol-4-yl)Oxy)Pyridin-2-yl)Amino)Pyridin-2-yl)Propan-2-Ol
- 中文名称4-[[4-[[1-环丙基-3-(四氢-2H-吡喃-4-基)-1H-吡唑-4-基]氧基]-2-吡啶基]氨基]-α,α-二甲基-2-吡啶甲醇
- IUPAC名称2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol
- CAS编号1898283-02-7
- MFCD编号:MFCD31619238
- FDA UNII编号:19HY34R6UN
- 分子式:C24H29N5O3分子量:435.53
- 产品CID: 961462
- 产品分类有机原料 → 有机氧化合物
物理性质
合成工艺路线路线简述
📜4-溴吡啶-2-甲酸乙酯置于ammonium Hydroxide,Palladium Diacetate,铜,Caesium Carbonate,4,5-双二苯基膦-9,9-二甲基氧杂蒽体系中,用 四氢呋喃,2-甲基四氢呋喃,1,4-二氧六环,水 用作溶剂,化学反应 0.5H,反应生成4-[[4-[[1-环丙基-3-(四氢-2H-吡喃-4-基)-1H-吡唑-4-基]氧基]-2-吡啶基]氨基]-Alpha,Alpha-二甲基-2-吡啶甲醇
参考文献:Aminopyridyloxypyrazole Compounds
标题:Aminopyridyloxypyrazole Compounds
摘要:本发明涉及新型氨基吡啶氧吡唑化合物,其抑制转化生长因子β受体1(tgfβr1)的活性,包括所述化合物的药物组合物,以及使用所述化合物治疗癌症的方法,优选结肠癌,黑色素瘤,肝细胞癌,肾癌,胶质母细胞瘤,胰腺癌,骨髓增生异常综合征,肺癌和胃癌,和/或纤维化,优选肝纤维化和慢性肾病.
海关参考信息
- 2905122000-异丙醇
2905130000-正丁醇
2909110000-乙醚
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[1]. Huaxing Pei, et al. Abstract955: LY3200882, a novel, highly selective TGFβRI small molecule inhibitor. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 955. https://aacrjournals.org/cancerres/article/77/13_Supplement/955/622127/Abstract-955-LY3200882-a-novel-highly-selective [2]. Xu G, Zhang Y, Wang H, Guo Z, Wang X, Li X, Chang S, Sun T, Yu Z, Xu T, Zhao L, Wang Y, Yu W. Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors. Eur J Med Chem. 2020 Jul 15;198:112354. doi: 10.1016/j.ejmech.2020.112354. Epub 2020 Apr 29.
合成参考文献
参考文献:10.1016/j.bmcl.2022.128552
摘要:Wang Z, Zhang Y, Wang H, Wang X, Yu Z, Zhao L. Synthesis and biological evaluation of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives as novel, potent of ALK5 receptor inhibitors. Bioorganic & Medicinal Chemistry Letters. 2022 Apr;61():128552. doi: 10.1016/j.bmcl.2022.128552.
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