CAS: 1730-91-2; (S)-2-Methylbutanoic Acid

相似化合物

116-53-0 32231-50-8 7452-79-1

上下游产品

CAS号80-59-1 惕格酸 | CAS号1565-80-6 S(-)-2-甲基-1-丁醇 | CAS号73-32-5 L-异亮氨酸 | CAS号79563-25-0 (4S)-3-[2-Methy... | CAS号77397-07-0 (S)-1-((S)-2-(h... | CAS号6565-55-5 1,3,5-Tris(1-me... | CAS号114862-03-2 N-[(R)-2-Hydrox... | CAS号1012054-37-3 (S)-(+)-(E)-S-e... | CAS号10307-60-5 (S)-2-甲基丁酸甲酯 | CAS号10574-37-5 2,3-二甲基-2-戊烯 | CAS号37526-88-8 惕各酸苄酯 | CAS号3739-30-8 2-羟基-2-甲基丁酸 | CAS号534-00-9 (S)-1-溴-2-甲基丁烷 | CAS号1730-92-3 (S)-3-甲基戊酸 | CAS号40560-30-3 (S)-(+)-(2-甲基丁基)苯 | CAS号73573-88-3 美伐他汀 | CAS号869-08-9 2-Methylbutyric... | CAS号78-92-2 仲丁醇

惕格酸置于2,氢气,三乙胺体系中,用 甲醇 用作溶剂,20.0 °C,405.3 Kpa 条件下,反应 24.0H,以100%的收率获得(S)-(+)-2-甲基丁酸
参考文献:与全套预制和现场制备的手性二膦-钌(II)催化剂进行对映选择性氢化反应.
标题:与全套预制和现场制备的手性二膦-钌(II)催化剂进行对映选择性氢化反应.
摘要:新型的2-甲基烯丙基钌手性二膦化合物1在α,β不饱和酸和烯丙醇的不对称加氢中有效.相关的手性含卤素的钌催化剂2由1或从(cod)ru(η)3-(ch 2)2 Chch 3)2原位制备.通过与螯合的二膦进行配体交换,然后在丙酮中进行质子化(hx).该方法允许在钌介导的前手性底物氢化中快速筛选手性膦,例如diop,Chiraphos,Cbd,Bppm,Binap,β-葡萄糖,Biphemp,Meo-Biphep,Me-Duphos.具有阻转异构体配体(ee高达99%)的ru催化剂显示出很高的效率,并且c 2对称的双(膦环烷)也作为有价值的配体出现了(me-Duphos,Ee高达87%尚未优化).β-酮酯的不对称氢化反应可以在相当温和的条件下进行(h 2为4 Atm.(例如,在50°C,Ee高达99%),具有双取代双键的β-酮酯也在控制的条件下以优异的光学纯度被化学选择性氢化为不饱和手性醇.
Doi:10.1016/0957-4166(94)80030-8

专利信息

专利号:US-2007088086-A1
优先权日:1999-08-16
标题 :Method of using synthetic L-Se-methylselenocysteine as a nutriceutical and a method of its synthesis
发明人：SPALLHOLZ JULIAN E; REID TED W; WALKUP ROBERT D
权利人:PHARMASE INC
摘要:A synthesis of and use for L-Se-methylselenocysteine as a nutriceutical is described, based upon the knowledge that L-Se-methylselenocysteine is less toxic than L-selenomethionine towards normal cells. The synthesis proceeds by mixing N-(tert-butoxycarbonyl)-L-serine with a dialkyl diazodicarboxylate and at least one of a trialkylphosphine, triarylphosphine, and phosphite to form a first mixture that includes N-(tert-butoxycarbonyl)-L-serine β-lactone. Methyl selenol or its salt is mixed with the N-(tert-butoxycarbonyl)-L-serine β-lactone to form a second mixture that includes N-(tert-butoxycarbonyl)-Se-methylselenocysteine. The tert-butoxycarbonyl group is removed from the N-(tert-butoxycarbonyl)-Se-methylselenocysteine to form L-Se-methylselenocysteine. This synthesis significantly improves the manufacturability, manufacturing efficiency, and utility of this naturally occurring rare form of organic-selenium. L-Se-methylselenocysteine formed, for example, in this manner may be used as a nutriceutical for supplementation into the diets of humans or animals for various beneficial purposes, such as, for example, to prevent or reduce the risk of developing cancer.

专利号:US-2024132460-A1
优先权日:2021-03-10
标题:Synthesis of tigilanol tiglate and analogs thereof
发明人：WENDER PAUL A; LUU NGUYEN HONG QUANG; GENTRY ZACHARY; NJOO EDWARD; FANELLI DAVID; MCATEER OWEN DENNIS
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Provided are methods for the isolation of phorbol from seed sources and the use of the phorbol for the generation of tigliane tiglate and derivatives thereof.

专利号:US-6194612-B1
优先权日:1995-10-17
标 题:Template for solution phase synthesis of combination libraries
发明人：BOGER DALE L; CHENG SOAN; MYERS PETER L
权利人:SCRIPPS RESEARCH INST; COMBICHEM INC
摘要:This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-5223415-A
优先权日:1990-10-15
标题 :Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
发明人：CONDER MICHAEL J; CIANCIOSI STEVEN J; COVER WILLIAM H; DABORA REBECCA L; PISK ERIC T; STIEBER ROBERT W; TEHLEWITZ BOGDAN; TEWALT GREGORY L
权利人:MERCK & CO INC
摘要:Biosynthetic production of 7-[1',2',6',-7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy -1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid, 'triol acid', is accomplished by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula ATCC 38009 or ATCC 74178, or mutants thereof, or a cell-free extract derived therefrom, or a hydrolase derived therefrom. The triol acid and its lactone form are both inhibitors of HMG-CoA reductase and thus useful as anti-hypercholesterolemic agents, and may also serve as intermediates for preparation of other HMG-CoA reductase inhibitors. Also, in the synthesis of simvastatin by direct methylation of lovastatin, selective hydrolysis of residual lovastatin salt by treatment with Clonostachys compactiuscula ATCC 38009 or ATCC 74178 or mutants thereof or a cell-free extract derived therefrom, or a hydrolase derived therefrom yields the 'triol' salt which can be easily separated from simvastatin.

专利号:US-8188304-B2
优先权日:2006-03-31
标 题:Process for the purification of lanthanide carboxylates
发明人：BIAGINI PAOLO; SALVALAGGIO MARIO; CAMBISI FRANCO; BONOLDI LUCIA; GILA LILIANA
权利人:BIAGINI PAOLO; SALVALAGGIO MARIO; CAMBISI FRANCO; BONOLDI LUCIA; GILA LILIANA; POLIMERI EUROPA SPA
摘要:A process is described for the purification of lanthanide carboxylates which comprises a step in which the hydrocarbon solution deriving from the synthesis of lanthanide carboxylate, containing said carboxylate and impurities of the corresponding carboxylic acid and/or water, is treated with an aqueous solution of a base in order to obtain a pH of the aqueous phase ranging from 9.0 to 12.2 and/or a step in which the hydrocarbon solution containing lanthanide carboxylate is treated with a solid selected from Na 2 SO 4 , MgSO 4 , Mg(ClO 4 ) 2 , molecular sieves 3 â„«, molecular sieves 4 â„«, molecular sieves 5 â„« and molecular sieves 13 X. Analytical methods are also described, which allow the purity of the lanthanide carboxylates to be non-destructively measured.

专利号:US-5521281-A
优先权日:1995-04-18
标题 :Substantially isotactic, linear, alternating copolymers of carbon monoxide and an olefin
发明人：SEN AYUSMAN; JIANG ZHAOZHONG
权利人:PENN STATE RES FOUND
摘要:The compound, [Pd(Me-DUPHOS)(MeCN)2](BF4)2, [Me-DUPHOS: 1,2-bis(2,5-dimethylphospholano)benzene] is an effective catalyst for the highly enantioselective, alternating copolymerization of olefins, such as aliphatic alpha -olefins, with carbon monoxide to form optically active, isotactic polymers which can serve as excellent starting materials for the synthesis of other classes of chiral polymers. For example, the complete reduction of a propylene-carbon monoxide copolymer resulted in the formation of a novel, optically active poly(1,4-alcohol). Also, the previously described catalyst is a catalyst for the novel alternating isomerization cooligomerization of 2-butene with carbon monoxide to form optically active, isotactic poly(1,5-ketone)