专利号:US-6005103-A 优先权日:1993-11-19 标题 :Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:WARNER LAMBERT CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
专利号:CN-108906124-A 优先权日:2017-03-17 标 题 :Application of Tricene Rare Earth Metal Complexes as Catalysts in the Synthesis of Ketones and Pinacol-Borane
专利号:CN-108906124-B 优先权日:2017-03-17 标题 :Application of trilocene rare earth metal complexes as catalysts in the synthesis of ketones and pinacol boranes
专利号:EP-0729465-B1 优先权日:1993-11-19 标 题:Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:PARKE DAVIS & CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
专利号:CN-111606910-A 优先权日:2020-06-30 标 题:A kind of synthesis process of antitumor drug Sapanisertib
专利号:US-9701686-B2 优先权日:2009-12-04 标题:Tricyclopyrazole derivatives 发明人:DISINGRINI TERESA; MANTEGANI SERGIO; VARASI MARIO 权利人:NERVIANO MEDICAL SCIENCES SRL 摘要:Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
参考标题:Chemo- And Regioselective Synthesis Of Acyl-Cyclohexenes By A Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade 作者:Lewis B. Smith,Roly J. Armstrong,Daniel Matheau-Raven,Timothy J. Donohoe |发布日期:2020.2.5 摘要:Acceptorless Dehydrogenation Of The Diol Followed By A Redox-Neutral Cascade Process, Which Is Independent Of The Iridium Catalyst. Deuterium Labeling Studies Established That The Key Step Of This Cascade Involves A Novel Base-Mediated [1,5]-Hydride Shift. The Cyclohexenyl Ketone Products Could Readily Be Cleaved Under Mildly Acidic Conditions To Access A Range Of Valuable Substituted Cyclohexene Derivatives
合成参考文献
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