CAS: 16331-46-7; 4-Ethoxybenzoyl Chloride

上下游产品

4-(ethoxy)benzoic acid 4-hydroxy-benzoic acid Ethyl 4-hydroxybenzoate ethyl 4-ethoxybenzoate 1-(4-ethoxy-benzoyl)-aziridine 4-ethoxydiazoacetophenone S-(2-morpholino-ethyl ester); hydr°Chloride4-ethoxy-thiobenzoic acid S-(2-morpholino-ethyl ester); hydr°Chloride 4-ethoxy-benzoic acid-[3-(2-methyl-piperidino)-propylester]; hydr°Chloride

对乙氧基苯甲酸置于氯化亚砜体系中,用 苯 用作溶剂,化学反应 3.0H,反应生成4-乙氧基苯甲酰氯
参考文献:一些新型抗菌苯甲酰胺的合成和分子对接研究.
标题:一些新型抗菌苯甲酰胺的合成和分子对接研究.
摘要:常规抗生素的普遍使用已导致许多致病菌耐药菌株的出现.因此,我们旨在合成许多n-(2-羟基-(4或5)-硝基苯基)苯甲酰胺衍生物作为一类新型的抗菌化合物.此外,我们的第二个目标是在结合模式下预测活性结构与酶(dna回转酶和ftsa)之间的相互作用.在这项研究中,合成了13种n-(2-羟基-(4或5-硝基苯基)-取代的苯甲酰胺,并用微量稀释法测定了它们的抗菌活性,根据这项工作,没有一种化合物显示出对念珠菌的任何活性.一些苯甲酰胺(4N1,5N1,5N2)对金黄色葡萄球菌和mssa的活性非常显着,Mic值<4 µg / Ml,即使发现它们比头孢他啶更有效.还发现4N1对粪肠球菌的临床分离株比庆大霉素更有效.分子对接研究表明,4N1,5N1和5N2与dna陀螺酶具有非常好的相互作用.而且,5N1也以结合模式与ftsa酶相互作用.只有化合物5N4对大肠杆菌atcc 25922表现出非常好的活性.这些发
Doi:10.1016/j.Bioorg.2019.103368

专利信息

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-2008176857-A1
优先权日:2005-03-25
标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2008280877-A1
优先权日:2007-05-10
标 题:Azetidines
发明人：DACK KEVIN NEIL; SKERRATT SARAH ELIZABETH; YEAP SIEW KUEN
权利人:PFIZER
摘要:The invention relates to EP2 antagonist azetidines of formula (I) n n n n n n n n n n wherein Ar, R 1 , X, and Z are as defined herein, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids, to intermediates useful in their synthesis, and to compositions containing them.

专利号:US-9115102-B2
优先权日:2009-09-17
标题 :N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors
发明人：CHAMBON SANDRINE; CLARY LAURENCE; SCHUPPLI MARLENE
权利人:CHAMBON SANDRINE; CLARY LAURENCE; SCHUPPLI MARLENE; GALDERMA RES & DEV
摘要:The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.