CAS: 1631-26-1; 1-Benzylpyrrole-2,5-Dione

上下游产品

trans-3-(benzylcarbamoyl)acrylic acid maleiimide benzyl alcohol N-benzylmaleamic acid2-benzyl-4,7-dimethyl-3a,4,7,7a-tetrahydro-4,7-epioxido-isoindole-1,3-dione 1'-benzyl-2',5'-dioxo-[7α,8α:3',4']-pyrrolidino-6,14-endoethenotetrahydrothebaine 1'-benzyl-[1,3'-bipyrrolidine]-2',5'-dione 1-benzyl-3-(piperidin-1-yl)pyrrolidine-2,5-dione

3-(Benzylamino)Prop-2-Enoic Acid置于sodium Acetate,乙酸酐体系中,化学反应 1.0H,以80%的收率获得n-苄基马来酰亚胺
参考文献:自挥发性聚合物的可变温度触发的热不稳定端盖小文库的制备和表征
标题:自挥发性聚合物的可变温度触发的热不稳定端盖小文库的制备和表征
摘要:呋喃与马来酰亚胺之间的反应已越来越成为一种令人感兴趣的方法,因为它的可逆性使其成为自修复材料,自毁聚合物,细胞培养用水凝胶和骨修复制剂等应用的有用工具.然而,这些应用中的大多数都依赖于简单的单取代呋喃和简单的马来酰亚胺,并且还没有广泛评估通过简单的底物修饰可实现的固有的潜在热变异性.准备了一个适合上述应用的小型环加合物库,并通过原位1确定了diels-Alder逆过程的温度依赖性.1 H NMR分析辅以计算计算.所报道的系统的实际温度范围为40至> 110oc.环还原反应比基于材料前沿分子轨道分析所预期的简单趋势所预期的复杂得多.
Doi:10.1021/acs.Joc.8B00135

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-6198000-B1
优先权日:1997-07-07
标 题:Intermediates useful in the synthesis of quinoline antibiotics
发明人：HAWKINS JOEL M
权利人:PFIZER
摘要:A process for preparing a compound of the formula n wherein R 1 , m, o and p are described below, which comprises adding a base of the formula n wherein R 2 , R 3 and R 4 are as described below, to a solution comprising a compound of the formula n wherein R 1 , m, o and p are as described below, and a halonitromethane of the formula O 2 NCH 2 X, wherein X is a halogen atom dissolved in a non-aqueous inert solvent. The compounds of formula III are useful as intermediates in the syntheses of azabicyclo quinoline carboxylic acids, and their pharmaceutically acceptable salts and prodrugs, having antibacterial activity. This invention also relates to the base of formula IV wherein each R 2 is butyl, R 3 is hydrogen and each R 4 is t-butyl.

专利号:US-5510516-A
优先权日:1990-07-06
标 题 :Process for selective epoxidation of unsaturated (meth)acrylates, new functional (meth)acrylates obtained and their application to the synthesis of new polymers
发明人：CAUBERE PAUL; FORT YVES; ORTAR AGNES
权利人:ATOCHEM
摘要:An unsaturated (meth) acrylic compound of formula: (I) (X=O, S, NH, NR3 (R3=C1-12-alkyl) or O-(CH2)n (where n=1-16 approximately); R2=C2-20 straight-chain or branched alkyl, monocyclic or polycyclic cycloalkyl or heterocycloalkyl, or alkylaryl hydrocarbon chain, comprising an olefinic double bond in the chain, or at the end of the chain in the case of alkyl or alkylaryl, or an exocyclic or endocyclic olefinic double bond in the case of monocyclic or polycyclic cycloalkyl or heterocycloalkyl; and R1=H or C1-5-alkyl), is reacted at 10 DEG -60 DEG C. with at least one oxidising compound (hydrogen peroxide) in the presence of at least one catalyst (alkali metal molybdates and tungstates) and in the presence of at least one phase transfer agent and when R2=polycyclic cycloalkyl or hetercycloalkyl, an organic peracid or hydrogen peroxide in the presence of at least one heteropolyacid. To open the epoxide function, the epoxide obtained is reacted with a compound chosen from strong inorganic acids, boron trifluoride etherate complexes, acid salts in the presence of the corresponding acid, halides of trialkylsilanes or trialkoxysilanes, and ketones in the presence of cationic resins.

专利号:US-7351781-B2
优先权日:2001-04-24
标题 :Synthesis of vinyl polymers by controlled radical polymerization
发明人：WHITE DANIELA; O'DWYER JAMES B
权利人:PPG IND OHIO INC
摘要:A controlled free radical polymerization process, which includes the steps of: adding a monofunctional iniferter compound to an oxygen-free solvent; heating the solution to a temperature sufficient to allow the iniferter compound to form two carbon centered radical residues; adding a first monomer composition comprising one or more monomers to the solution containing the radical containing residues; polymerizing the first monomer composition to form a quasi-living polymer; and optionally polymerizing a second monomer composition comprising one or more monomers, which are different than the first monomer composition. The resulting non-random copolymer having the general formula:n nφ-[-A p -B s -] t -φn nwhere A and B are different compositions of ethylenically unsaturated monomers; p is an integer from 1 to 1,000; s is an integer from 0 to 1,000; t is an integer from 1 to 100; and φ is a residue from the iniferter.

专利号:EP-0627420-B1
优先权日:1992-01-30
标 题 :Process for the synthesis of maleimide compound improved in storage stability
发明人：KITA YUICHI; NAKAGAWA KOICHI; KISHINO KAZUO
权利人:NIPPON CATALYTIC CHEM IND
摘要:A stabilized maleimide compound which is hardly discolored during storage, wherein the content of primary amines is 500 ppm or less, that of maleic anhydride is 5-2,000 ppm, and that of 2-amino-N-substituted succinimide is 300 ppm or less. It is preferable that the content of chlorine compounds be 10 ppm or less in terms of chlorine and that of volatile components having each a boiling point of 200 °C or below under an ordinary pressure be 2,000 ppm or less.