CAS: 1513-69-5; 2-Amino-4-Hydroxy-6-(Trifluoromethyl)Pyrimidine

相似化合物

1546-78-7 1340265-01-1 1342237-49-3

📜硝酸胍,三氟乙酰乙酸乙酯置于sodium Butanolate体系中,用 正丁醇 用作溶剂,化学反应 6.0H,以83%的收率获得2-氨基-4-羟基-6-(三氟甲基)嘧啶
参考文献:Synthesis And In Vitro Antitumor Activity Of Novel Diaryl Urea Derivatives
标题:Synthesis And In Vitro Antitumor Activity Of Novel Diaryl Urea Derivatives
摘要:A Series Of Novel Diaryl Ureas Containing 4-[(2-Amino-6-Trifluromethyl)Pyrimidine-4-Yl]Piperazine-1-Yl Group Were Synthesized And Evaluated For Their Cytotoxic Activities In A Panel Of Human Cancer Cell Lines. Compared With The Reference Drug Sorafenib,Some Compounds Showed More Potent And A Broader Spectrum Of Anti-Cancer Activities. Among Them,Compound 2P Demonstrated Significant Inhibitory Activities Against Mda-Mb-231,Ht-29 And Mcf-7 Cell Lines With Ic50 Values Of 0.016,0.63,0.001 Mu Mol/l,Respectively. (C) 2013 Ping Gong. Published By Elsevier B.V. On Behalf Of Chinese Chemical Society. All Rights Reserved.
Doi:10.1016/j.Cclet.2013.02.004

专利信息

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D†). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.