CAS: 144292-32-0; 4-Bromo-2,3-Difluorophenol

相似化合物

1998-61-4 486424-36-6 186590-26-1

上下游产品

CAS号6418-38-8 2,3-二氟苯酚 | CAS号406482-22-2 4-溴-2,3-二氟苯甲醚 | CAS号144292-53-5 1-(苄氧基)-2,3-二氟苯 | CAS号941294-52-6 1-(苄氧基)-4-溴-2,3-二氟苯 | CAS号212386-71-5 2,3-二氟-4-乙氧基苯硼酸 | CAS号156573-09-0 4-溴-2,3-二氟苯乙醚

2,3-二氟苯酚置于溶剂黄146,Potassium Bromide体系中,用 水,溶剂黄146 用作溶剂,以73%的收率获得4-溴-2,3-二氟苯酚
参考文献:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
标题:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
摘要:以 Kbr 和 Znal-Bro3--层状双氢氧化物(缩写为 Znal-Bro3--Ldhs)作为溴化试剂,成功开发了苯酚的区域选择性单溴化反应.对位点比较有利,如果对位点被占用,则邻位点优先.该反应具有优异的区域选择性,廉价的溴化试剂,反应条件温和,原子经济性高,底物范围广等特点,为溴代苯酚的合成提供了一种有效的方法.
Doi:10.3390/molecules25040914

专利信息

专利号:US-7902394-B2
优先权日:2006-12-18
标题:Calcilytic compounds
发明人：MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT
权利人:GLAXOSMITHKLINE LLC
摘要:Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.