CAS: 14377-68-5; 1-Phenylcyclobutanecarbonitrile

该化合物是一种专门的有机化合物,其特点是以一个苯基组和一个微微分功能组取代环丁烷环环,在同一碳中心有一个微微微分功能组.这种结构具有独特的反应性,使其作为合成有机化学的中间体具有价值,特别是在制药,农用化学品和精细化学剂的准备方面.硝基子组提供了多种变异潜力,能够进一步转化为氨,碳酸或异体循环体.其硬性环丁烷骨骨可能助长目标分子的...

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37828-19-6 1469-83-6 17380-65-3

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CAS号140-29-4 苯乙腈 | CAS号109-64-8 1,3-二溴丙烷 | CAS号142-28-9 1,3-二氯丙烷 | CAS号37828-19-6 1-苯基环丁烷-1-羧酸 | CAS号1007-70-1 Benzene,(1-meth... | CAS号1469-83-6 1-Phenyl-cyclob... | CAS号17380-65-3 1-苯基-环丁烷羧酰胺 | CAS号17380-77-7 1-苯基环丁胺 | CAS号811803-25-5 1-(4-氨基-苯基)-环丁烷甲腈 | CAS号91245-59-9 (1-苯基环丁基)甲胺 | CAS号4620-67-1 1-苯基环丁烷羰酰氯 | CAS号3972-67-6 1-(1-苯基环丁基)乙酮

合成工艺路线路线简述

    苯乙腈置于氨,Sodium Amide体系中,化学反应生成1-苯基环丁烷甲腈
    参考文献:Aminoesters Of Substituted Alicylic Carboxylic Acids1
    标题:Aminoesters Of Substituted Alicylic Carboxylic Acids1
    摘要:
    Doi:10.1021/ja01203A077

    海关参考信息

    专利信息


    专利号:US-9834556-B2
    优先权日:2014-03-24
    标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine
    发明人:BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P
    权利人:ARQULE INC
    摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:

    专利号:US-7816375-B2
    优先权日:2000-09-11
    标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
    发明人:AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
    权利人:SEPRACOR INC
    摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

    专利号:US-9695116-B2
    优先权日:2011-12-30
    标题:Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
    发明人:BHAT LAXMINARAYAN; ADIEY KOUACOU; BHAT SEEMA RANI
    权利人:REVIVA PHARMACEUTICALS INC
    摘要:The present invention provides novel phenylcycloalkylmethylamine derivatives, and methods of preparing phenylcycloalkylmethylamine derivatives. The present invention also provides methods of using phenylcycloalkylmethylamine derivatives and compositions of phenylcycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

    专利号:US-9302981-B2
    优先权日:2006-09-15
    标 题:Synthesis, methods of using, and compositions of cycloalkylmethylamines
    发明人:BHAT LAXMINARAYAN; BHAT SEEMA RANI
    权利人:REVIVA PHARMACEUTICALS INC
    摘要:The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.

    专利号:US-8669285-B2
    优先权日:2006-09-15
    标题 :Synthesis, methods of using, and compositions of cycloalkylmethylamines

    专利号:US-2008139663-A1
    优先权日:2006-09-15
    标 题 :Synthesis, methods of using, and compositions of cycloalkylmethylamines
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    主要参考文献

    参考标题:Fe(Clo4)3.H2O-Catalyzed Ritter Reaction: A Convenient Synthesis Of Amides From Esters And Nitriles
    作者:Min Ji,Chengliang Feng,Bin Yan,Guibo Yin,Junqing Chen |发布日期:2018.10
    摘要:An Efficient And Inexpensive Synthesis Of N-Substituted Amides From The Ritter Reaction Of Nitriles With Esters Catalyzed By Fe(Clo4)3.H2O Is Described. Fe(Clo4)3.H2O Is An Economically Efficient Catalyst For The Ritter Reaction Under Solvent-Free Conditions. Reactions Of A Range Of Esters (Benzyl, Sec-Alkyl, And Tert-Butyl Esters) With Nitriles (Primary, Secondary, Tertiary, And Aryl Nitriles) Were
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