CAS: 142763-10-8; (R)-2-Chloro-1-(3-Chlorophenyl)Ethan-1-Ol

该化合物是一种手性有机化合物,其特点是存在氯化苯基组和酒精功能组,其分子结构是第二碳的手性中心,有助于其立体化学,特别是(R)配置.该化合物一般没有色素,可粉黄液体,在有机溶剂中可溶解,反映了其因氯联苯混合物而具有的疏水特性.乙基和苯组中氯原子的存在,增强了其再活动性和在有机合成和药用化学中的潜在应用.它可能展示生物活动,使其在制药研究中引起兴趣.此外,该化合物的沸点和密度等特性可因环境条件和纯度而不同.在处理该物质时,安全因素至关重要,因为它的氯化性质可能会对健康造成危害.

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6378-66-1 178460-80-5 178460-78-1

上下游产品

3-chlorophenacyl chloride (+)-2-chloro-1-(3-chlorophenyl)ethanol 3'-Chloroacetophenone 3-chlorostyrene oxide (R)-meta-chlorostyrene oxide (1R)-2-amino-1-(3-chloro-phenyl)-ethanol hydr°Chloride (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-ethanol (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(3,4-dihydroxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one

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    专利信息


    专利号:US-2004219658-A1
    优先权日:2001-06-25
    标 题 :Process for producing optically active (r)-2-chloro-1-(3'-chlorophenly) ethanol
    发明人:SHIMIZU SAKAYU; KATAOKA MICHIHIKO; KIZAKI NORIYUKI; YASOHARA YOSHIHIKO
    权利人:SHIMIZU SAKAYU; KATAOKA MICHIHIKO; KIZAKI NORIYUKI; YASOHARA YOSHIHIKO
    摘要:The present invention discloses a process for efficiently producing, on an industrial scale, optically active (R)-2-chloro-1-(3′-chlorophenyl)ethanol which is useful as a raw material for the synthesis of medicines, agricultural chemicals, etc. n The process includes allowing cells of a microorganism or a material prepared by treating the cells of the microorganism to act on 2-chloro-1-(3′-chlorophenyl)ethanone to produce (R)-2-chloro-1-(3′-chlorophenyl)ethanol, the microorganism being capable of stereoselectively reducing 2-chloro-1-(3′-chlorophenyl)ethanone to yield (R)-2-chloro-1-(3′-chlorophenyl)ethanol.

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    合成参考文献


    参考文献:10.1007/978-3-319-24862-2_5
    摘要:Tischler D. Biotechnological Applications of Styrene-Degrading Microorganisms or Involved Enzymes. 2015. In: SpringerBriefs in Microbiology.
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