CAS: 13865-19-5; Methyl 4-Oxobutanoate

相似化合物

106-65-0 1070-34-4 110-15-6

上下游产品

丁二酸单甲酯 Monomethyl Succinate 3878-55-5
丁二酸二甲酯 Dimethyl Succinate 106-65-0
4-羟基丁酸甲酯 Methyl 4-Hydroxybutanoate 925-57-5
γ-丁内酯 4-Butanolide 96-48-0
琥珀半醛 Succinic Semialdehyde 692-29-5
4-戊烯酸甲酯 Methyl 4-Pentenoate 818-57-5
丁二酸单甲酯酰氯 Succinic Acid Monomethylester Chloride 1490-25-1

丁二酸单甲酯置于palladium On Activated Charcoal 2,6-二甲基吡啶,草酰氯,氢气,N,N-二甲基甲酰胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 3.0H,反应生成乙酰乙酸甲酯
参考文献:2-降白三烯类似物的合成及其ltd4拮抗剂活性.
标题:2-降白三烯类似物的合成及其ltd4拮抗剂活性.
摘要:合成了一系列4(R)-羟基-5(S)-半胱氨酰甘氨酰基-6(z)-十九碳烯酸[4R,5S,6Z)-2-Nor-Ltd1(10B,Sk&f 101132)的结构类似物和药理学特征.(4R,5S,6Z)-2-Nor-Ltd1显着拮抗ltd4诱导的对豚鼠气管的收缩反应.顺式双键几何形状似乎对拮抗剂活性至关重要,而反式异构体17表现出较弱的收缩活性.用半胱氨酸代替半胱氨酰糖基部分得到20,其保留了显着的拮抗剂活性,同时通过五个亚甲基延长或缩短脂质尾巴导致活性完全丧失.类花生酸酰胺15,甘氨酰胺14和c-1甲醇18类似物均具有拮抗活性,
Doi:10.1021/jm00150A016

专利信息

专利号:WO-2009030733-A1
优先权日:2007-09-04
标 题 :Method for the synthesis of 4-alkoxy-, 4-hydroxy- and 4-aryloxy-substituted tetrahydro-furo[3,4-b]furan-2(3h)-one compounds
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; ALSTERS PAULUS LAMBERTUS; STRAATMAN HENRICUS MARTINUS MARIO; HANBAUER MARTIN HELMUT FRIEDRICK
权利人:DSM IP ASSETS BV; QUAEDFLIEG PETER JAN LEONARD MARIO; ALSTERS PAULUS LAMBERTUS; STRAATMAN HENRICUS MARTINUS MARIA GERARDUS; HANBAUER MARTIN HELMUT FRIEDRI
摘要:The present invention relates to a method for the synthesis of enantiomerically and diastereomerically enriched 4-alkoxy-, 4-hydroxy- or 4-aryloxy- substituted tetrahydro-furo[3,4-b]furan-2(3H)-ones by aldol coupling of a suitable hydroxyl-protected hydroxy-acetaldehyde and 4-oxobutanoic acid or an ester thereof, and subsequent removal of the protecting group from the aldol compound and (optionally simultaneous) cyclizations and acetal formation under acidic conditions in the presence of an alcohol, followed by optional isolation of the desired compounds. The invention also relates to compounds according to formulae [Xl] and [XII].

专利号:US-2010159540-A1
优先权日:2007-03-26
标题:Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
发明人：RODRIGUEZ ANA; SPUR BERND
权利人:RODRIGUEZ ANA; SPUR BERND
摘要:Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.

专利号:US-7034154-B2
优先权日:1999-08-10
标 题:Synthesis of substituted pyrazolopyrimidines
发明人：GROSS RAYMOND S; WILCOXEN KEITH M; OGLESBY RICHARD CHRISTOPHER
权利人:NEUROCRINE BIOSCIENCES INC
摘要:Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and/or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.

专利号:US-4370258-A
优先权日:1978-03-09
标题 :Catalyst system for hydroformylation of olefins
发明人：OGATA IKUEI; KAWABATA YASUZIRO; TANAKA MASATO; HAYASHI TERUYUKI
权利人:AGENCY IND SCIENCE TECHN
摘要:An improved hydroformylation process for preparing aldehydes by reacting olefins with synthesis gas (H2 and CO) under heating and pressure is disclosed. The hydroformylation is carried out in the presence of a platinum catalyst, and assistant composed of a halide of a metal of the group IVb of the Periodic Table and a reaction promotor composed of a specific bidentate ligand of the formula R2X-Z-Y-Z-X-R'2. In this reaction, the platinum catalyst exerts a high activity, and an aldehyde mixture containing a linear isomer at a very high ratio of content is obtained as a product.

专利号:US-2003096374-A1
优先权日:1999-01-27
标题:Synthesis of oligoketides

专利号:US-5232929-A
优先权日:1990-11-28
标 题 :3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
发明人：DESAI MANOJ C; ROSEN TERRY J
权利人:PFIZER
摘要:The present invention relates to novel 3-aminopiperidine derivatives and related nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Y and m are as defined below. These novel compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders. The invention also relates to novel intermediates used in the synthesis of compounds of the formula I.