CAS: 129409-01-4; 2,2-(1E,1E)-(Ethane-1,2-Diylbis(Azan-1-Yl-1-Ylidene))Bis(Methan-1-Yl-1-Ylidene)Diphenol

专利信息

专利号:US-10053406-B2
优先权日:2015-10-23
标题 :Synthesis of honokiol
发明人：JARACZ STANISLAV; KOZLOWSKI MARISA; EUN LEE YOUNG; KIM SUN MIN
权利人:COLGATE PALMOLIVE CO; UNIV PENNSYLVANIA
摘要:Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.

专利号:US-9233943-B2
优先权日:2012-01-10
标题:Process for synthesis of syn azido epdxide and its use as intermediate for the synthesis of amprenavir and saquinavir
发明人：GADAKH SUNITA KHANDERAO; REKULA REDDY SANTHOSH; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:A novel synthetic route to the syn-azido epoxide of formula 5 includes cobalt-catalyzed hydrolytic kinetic resolution of a racemic mixture of the azido-epoxide. Reaction steps include subjecting an allylic alcohol to epoxidation with mCPBA to obtain a racemic epoxy alcohol; ring opening the epoxy alcohol with azide anion to obtain an anti-azido alcohol, which can then be selectively tosylated at the primary alcohol; treating the tosylate with base to obtain the racemic azido-epoxide; and subjecting the racemic azido-epoxide to cobalt-catalyzed hydrolytic kinetic resolution to obtain the syn-azido epoxide of formula 5. The compound of formula 5 may be used as a common intermediate for the asymmetric synthesis of HIV protease inhibitors, such as Amprenavir, Fosamprenavir, Saquinavir, and formal synthesis of Darunavir and Palinavir.

专利号:WO-2016120890-A1
优先权日:2015-01-30
标题 :An enantioselective process for the synthesis of (2s,4r)-4-hydroxypipecolic acid
发明人：SURYAVANSHI GURUNATH; KAMBLE ROHIT BALKRISHNA
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for synthesis of 4-hydroxy pipecolic acid. The present invention relates to an improved enantioselective process for the synthesis of (2S,4R)-4-hydroxypipecolic acid via Co(III) (salen)-catalyzed two stereocentered Hydrolytic Kinetic Resolution (HKR) of racemic 1,3-azido epoxide with good yields and high optical purity without any protecting groups. 10 31

专利号:US-7423171-B2
优先权日:2006-06-20
标题 :One-step catalytic process for the synthesis of isocyanates
发明人：SERRANO FERNANDEZ FRANCISCO LU; ALMENA MUNOZ BEATRIZ; PADILLA POLO ANA; OREJON ALVAREZ ARANCHA; CLAVER CABRERO CARMEN; CASTILLON MIRANDA SERGIO; SALAGRE CARNERO PILAR; AGHMIZ ALI
权利人:REPSOL YPF SA
摘要:A one-pot process for the synthesis of isocyanates, polyisocyanates or mixtures thereof which includes the steps of:n i. preparing a mixture comprising an amine, an alcohol, an oxygen-containing gas, carbon monoxide, a metal complex catalyst selected from the group consisting of macrocyclic complex catalysts and cobalt Shiff base catalysts; and a solvent selected from the group consisting of aliphatic or aromatic halocarbons, perhalogenated alcohols, halogenated ethers, halogenated ketones, perfluorinated hydrocarbons, polymers of chlorotrifluoroethylene having the formula —(CF 2 —CFCl) n wherein n is between 2 and 10, and mixtures thereof; ii. subjecting the resulting mixture to a first heating under pressure; iii. cooling and depressurizing the mixture resulting from the previous step; and iv. subjecting the mixture of the previous step to a second heating to separate out the isocyanate product from the mixture.

专利号:US-11441163-B2
优先权日:2020-05-14
标 题:Enzyme-catalyzed synthesis of (1S,5R)-bicyclolactone
发明人：CHEN FENER; ZHU KEJIE; HUANG ZEDU; CHENG DANG; WANG JIAQI; TAO YUAN
权利人:UNIV FUDAN
摘要:An enzyme-catalyzed synthesis of (1S,5R)-bicyclolactone. A first genetically-engineered bacterium containing Baeyer-Villiger monooxygenase gene and a second genetically-engineered bacterium containing glucose dehydrogenase gene are constructed and then suspended with culture medium to prepare a first suspension and a second suspension, respectively. The first and second suspensions are centrifuged to respectively produce a first supernatant containing Baeyer-Villiger monooxygenase and a second supernatant containing glucose dehydrogenase, which are mixed. The mixed supernatant is then mixed with a raceme of a substituted bicyclo[3.2.0]-hept-2-en-6-one, a solvent, a hydrogen donor and a cofactor to perform an asymmetric Baeyer-Villiger oxidation to produce the (1S,5R)-bicyclolactone, where an amino acid sequence of the Baeyer-Villiger monooxygenase is shown in SEQ ID NO:1.

专利号:US-11753503-B2
优先权日:2018-05-17
标 题:Supported onium salts as initiators for the synthesis of polycarbonates by copolymerization of CO2 with epoxides
发明人：FENG XIAOSHUANG; PATIL NAGANATHA; LUCIANI CAROLINE; GNANOU YVES; HADJICHRISTIDIS NIKOS
权利人:UNIV KING ABDULLAH SCI & TECH
摘要:Supported onium salts used as initiators for the synthesis of polycarbonates by copolymerization of carbon dioxide with epoxides are described. Embodiments of the present disclosure describe initiators comprising an insoluble portion including an onium cation attached to an insoluble support; and an anion, wherein the anion is a counter-ion to the onium cation. Embodiments further describe methods of making polycarbonates using the initiator, methods of making initiators, and the like.