CAS: 126889-55-2; Diethylisopropylsilyl Trifluoromethanesulfonate

该化合物是一种化学化合物,其特点是强酸性和反应性强,典型的三氟甲烷硫酸衍生物,其特点是三氟甲烷硫酸衍生物,该化合物具有很强的电益特性,使其在各种有机合成应用中,特别是在形成全氟辛烷磺酸酯时有用;二乙基丙基硅酸混合物的存在,增强了其稳定性和溶性,便于其在需要稳定的硅保护组的响应中使用;此外,三氟甲基化合物具有其独特的特性,例如,在制药和农用化学中增加脂性及潜在用途;由于其很强的酸性,必须谨慎处理,因为它能够与碱和核糖化合物进行强烈反应;

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79271-56-0 80522-42-5 79271-56-0

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上下游产品

trifluorormethanesulfonic acid chlorodiethylisopropylsilane(2S,3R,4R,5R,6R)-2,3,4-Tris-benzyloxy-5-(diethyl-isopropyl-silanyloxy)-6-(diethyl-isopropyl-silanyloxymethyl)-cyclohexanone 1-[(E)-(1R,2S,3R,6R)-1-[(1R,3S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,3-dimethyl-butyl]-3-(diethyl-isopropyl-silanyloxy)-2-methoxy-4,6-dimethyl-7-phenylsulfanyl-hept-4-enyloxymethyl]-4-methoxy-benzene phenyl 2,6-anhydro-3-O-(diethylisopropylsilyl)-4-O-isobutyryl-3-C-methyl-1,2-dithio-L-mannopyranoside (1R,4S,5R,6S)-4-Allyl-4-(diethyl-isopropyl-silanyloxy)-6-(4-methoxy-benzyloxymethyl)-2-oxa-bicyclo[3.2.1]°Ctan-3-one

合成工艺路线路线简述

    📜二乙基异丙基氯硅烷 以91%的收率获得
    参考文献:Toshima,Kazunobu;Mukaiyama,Satsuki;Kinoshita,Mitsuhiro;Tatsuta,Kuniak+,Tetrahedron Lett.,30,(1989) N6,C. 6413-6416
    标题:Toshima,Kazunobu;Mukaiyama,Satsuki;Kinoshita,Mitsuhiro;Tatsuta,Kuniak+,Tetrahedron Lett.,30,(1989) N6,C. 6413-6416

    海关参考信息

    专利信息


    专利号:US-10683318-B2
    优先权日:2014-10-17
    标 题:Scalable synthesis of reduced toxicity derivative of amphotericin B
    发明人：BURKE MARTIN D; UNO BRICE E; RAKSHIT SOUVIK
    权利人:UNIV ILLINOIS
    摘要:Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.

    专利号:US-2017233427-A1
    优先权日:2014-10-17
    标题 :Scalable synthesis of reduced toxicity derivative of amphotericin b

    专利号:US-2019127412-A1
    优先权日:2014-10-17
    标题 :Scalable synthesis of reduced toxicity derivative of amphotericin b

    专利号:US-10087206-B2
    优先权日:2014-10-17
    标题:Scalable synthesis of reduced toxicity derivative of amphotericin B

    专利号:EP-3206695-A1
    优先权日:2014-10-17
    标 题:Scalable synthesis of reduced toxicity derivative of amphotericin b

    专利号:WO-2016061437-A1
    优先权日:2014-10-17
    标 题 :Scalable synthesis of reduced toxicity derivative of amphotericin b

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    合成参考文献

    合成方法参考DOI号:10.1016/S0040-4039(01)93909-7
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