CAS: 1258984-36-9; Nusinersen

专利信息

专利号:US-2024384319-A1
优先权日:2021-09-17
标题 :Synthesis of Oligonucleotides
发明人：LOVELOCK SARAH
权利人:UNIV MANCHESTER
摘要:The present invention relates to a novel method for oligonucleotide synthesis, using a catalytic primer-template, e.g. a hairpin primer, to achieve multiple rounds of oligonucleotide synthesis and dissociation from the template in the same reaction, such that at the end of the reaction the amount of oligonucleotide generated is greater than the amount of template provided in the reaction. The primer contains a cleavable site and the reaction is carried out in a single mixture with a cleavage agent. The cleavable site may be an inosine and the agent an endonuclease V.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:WO-2024119625-A1
优先权日:2022-12-08
标题 :Synthesis method for double-stranded rna and use of rna ligase in double-stranded rna synthesis
发明人：HONG HAO; JAMES GAGE; ZHANG NA; JIAO XUECHENG; LIU FANG; MA CUIPING; WANG ZHAOSHUAI; Geng Yuhan; CUI LIXIN; ZHU WENXUAN; JIA XU; YANG YIMING; LI JUAN
权利人:ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
摘要:Disclosed are a synthesis method for double-stranded RNA and use of an RNA ligase in double-stranded RNA synthesis. The synthesis method comprises the following steps: S1, synthesizing single-stranded RNA fragments; and S2, mixing the single-stranded RNA fragments and linking the single-stranded RNA fragments using the RNA ligase to form the double-stranded RNA. The RNA ligase is an RNA ligase derived from Vibrio phage, Escherichia phage, Klebsiella phage, or the like. By means of applying the technical scheme of the present invention, different nucleotide fragments can be specifically spliced, so that long-fragment nucleotide strands can be synthesized; meanwhile, the linkage of natural nucleotides and non-natural nucleotides can be catalyzed, thus solving the technical problems of synthesizing nucleotide strands at present.

专利号:WO-2023041931-A1
优先权日:2021-09-17
标 题:Synthesis of oligonucleotides

专利号:US-2025026780-A1
优先权日:2018-05-02
标题:Optically Active Segment for Use in Synthesis of Stereocontrolled Oligonucleotide, Method for Producing the Same, and Method for Synthesizing Stereocontrolled Oligonucleotide Using the Same

专利号:EP-4402277-A1
优先权日:2021-09-17
标题:Synthesis of oligonucleotides