CAS: 121505-93-9; Tert-Butyl (2-(Methoxy(Methyl)Amino)-2-Oxoethyl)Carbamate

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CAS号4530-20-5 B°C-甘氨酸 | CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号1117-97-1 甲氧基甲基胺 | CAS号31954-27-5 B°C-甘氨酸甲酯 | CAS号3392-07-2 B°C-甘氨酸-N-羟基琥柏酰亚胺酯 | CAS号92136-39-5 N-B°C-炔丙基铵 | CAS号180913-22-8 2-Butenoicacid,... | CAS号93-60-7 烟酸甲酯 | CAS号854927-70-1 6-(2-tert-butox... | CAS号89711-08-0 N-B°C-2-氨基乙醛 | CAS号339185-69-2 N-[2-(3-溴苯基)-2-... | CAS号163625-26-1 2-is°Cyano-N-me... | CAS号170384-29-9 N-B°C-1-氨基丙酮 | CAS号76477-26-4 (2-氧代-2-苯乙基)-氨基甲酸叔丁酯 | CAS号832077-46-0 tert-butyl N-[2...

Boc-甘氨酸置于1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺,二甲羟胺盐酸盐体系中,用 二氯甲烷 用作溶剂,化学反应 17.0H,反应生成N-(叔丁氧基羰基)甘氨酸-N'-甲氧基-N'-甲酰胺
参考文献:Heterocyclic Compounds And Uses Thereof
标题:Heterocyclic Compounds And Uses Thereof
摘要:本文描述了调节激酶活性的化合物和药物组合物,包括pi3激酶活性,以及与激酶活性相关的疾病和病况的治疗方法,包括pi3激酶活性的化合物,药物组合物和治疗方法.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2009275727-A1
优先权日:1998-03-24
标题:Peptide turn mimetics
发明人：CASSIDY PETER J; ALEWOOD PAUL FRANCIS; VERNALL ANDREA JOY
权利人:MIMETICA PTY LTD
摘要:This invention provides novel compounds useful for the synthesis of peptide mimetics, and describes the use of these compounds for the synthesis of novel reverse turn mimetics. The reverse turn mimetics of the invention have the general structure X wherein the variables are as defined herein.

专利号:US-6534530-B1
优先权日:1999-08-04
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER SCOTT; ZHOU RU; WEBBER STEPHEN EVAN; PRINS THOMAS J; REICH SIEGFRIED HEINZ; KEPHART SUSAN E; RUI YUANJIN
权利人:AGOURON PHARMA
摘要:Compounds of the formula:where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:WO-2009045497-A1
优先权日:2007-10-04
标题 :Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:US-2010113305-A1
优先权日:1999-03-22
标题:Oxazole and thiazole combinatorial libraries
发明人：MARTIN LENORE M; HU BI-HUANG
权利人:RHODE ISLAND EDUCATION
摘要:This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acids containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.