CAS: 11089-65-9; Tunicamycin

专利信息

专利号:US-6376475-B1
优先权日:1997-05-30
标 题 :Control of immune responses by modulating activity of glycosyltransferases
发明人：MARTH JAMEY D; PAULSON JAMES C
权利人:ABARON BIOSCIENCES INC; UNIV CALIFORNIA
摘要:The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of α2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of α2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.

专利号:US-6083911-A
优先权日:1998-12-10
标题:Arenavirus receptor and methods of use
发明人：CAMPBELL KEVIN P; HENRY MICHAEL; YAMADA HIROKI; WILLIAMSON ROGER; CAO WEI; OLDSTONE MICHAEL
权利人:UNIV IOWA RES FOUND; SCRIPPS RESEARCH INST
摘要:Disclosed is a method for inhibiting the binding of an arenavirus to a cellular receptor. The method involves providing, in soluble form, a reagent comprising α-dystroglycan or a portion thereof, the reagent being characterized by the ability to bind to the arenavirus thereby inhibiting the binding of the arenavirus to the cellular receptor. The reagent is contacted with an arenavirus particle prior to infection of a cell by the arenavirus particle. Also disclosed are methods for treating an arenavirus infection in a patient and preventing an arenavirus infection in an individual at risk. These methods involve providing a therapeutic composition comprising α-dystroglycan or a portion thereof which is characterized by the ability to bind to arenaviruses, thereby inhibiting the binding of arenaviruses to a cellular receptor; and administering the composition to the patient or individual at risk. Arenaviruses to which the methods of the present invention apply include, without limitation, Lymphocyte Choriomeningitis Virus, Lassa fever virus, Mobala, and Oliveros. In another aspect, the disclosure relates to an embryonic stem cell line, and cells derived therefrom, which is homozygous for a disrupted dystroglycan gene, wherein the disruption prevents the synthesis of functional dystroglycan in the cells. Applications of the dystroglycan null embryonic stem cells include producing dystroglycan or a portion thereof in the cells and also for identifying portions of dystroglycan necessary for arenavirus infection. Also disclosed is a method for identifying antiviral compounds which interfere specifically with the binding of arenavirus and α-dystroglycan, comprising providing a binding assay system for the determination of binding of arenavirus and α-dystroglycan. The candidate antiviral compounds are introduced into the binding assay system and antiviral compounds which substantially inhibit binding of arenavirus to α-dystroglycan are identified.

专利号:US-8802380-B2
优先权日:2007-06-04
标 题 :Method for testing or screening protein synthesis inhibitors
发明人：DREYFUSS GIDEON; KASIM MUMTAZ
权利人:DREYFUSS GIDEON; KASIM MUMTAZ; UNIV PENNSYLVANIA
摘要:This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus. Additionally, the invention provides a kit and a system for screening protein synthesis inhibitors in a cell.

专利号:US-6955886-B1
优先权日:1998-05-15
标题:Scintillation proximity assay for the detection of peptidoglycan synthesis
发明人：DESOUSA SUNITA; PRAHLAD DWARAKANATH
权利人:ASTRAZENECA AB
摘要:The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan synthesis.

专利号:US-2004116371-A1
优先权日:2002-09-30
标 题 :Methods for polysaccharide adhesion synthesis modulation
发明人：ROMEO TONY; WANG XIN
摘要:There is provided a method for modulation of polysaccharide adhesin synthesis involving products of the ycdSRQP gene operon in bacteria, depicted in SEQ. ID. NO. 1 and 2. Also provided is the use of an inhibitor of a product of the ycdSRQP operon in improving the response of a mammalian patient suffering from a bacterial infection.

专利号:WO-9967419-A1
优先权日:1998-06-25
标题 :β(1,6)-GLUCAN SYNTHESIS AND CELL WALL ASSEMBLY ASSAY
发明人：OSTROFF GARY R
权利人:COLLABORATIVE GROUP LTD; OSTROFF GARY R
摘要:Methods are disclosed for assessing an agent for an ability to inhibit β(1,6)-glucan synthesis and/or incorporation of β(1,6)-glucan into the cell wall, comprising contacting samples of yeast cells that are sensitive to a killer toxin that targets β(1,6)-glucan with a test agent and a lethal dose of the killer toxin, and/or contacting samples of yeast cells that are sensitive to the killer toxin with a test agent and a sublethal dose of the killer toxin, and assessing the permeability of the cells in the samples, such as by using a membrane-impermeable dye that fluoresces on contact with DNA.