CAS: 108050-54-0; Tilmicosin

上下游产品

泰乐菌素b Tylosin B 11032-98-7
20-Dihydrotylosin 1404-48-4

20-Dihydrotylosin置于盐酸,Sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,碳酸氢钠,Potassium Bromide,Sodium Hydroxide体系中,用 水,乙酸乙酯 用作溶剂,化学反应 12.5H,反应生成替米考星
参考文献:一种以泰乐菌素d为原料制备替米考星的方 法
标题:一种以泰乐菌素d为原料制备替米考星的方 法
摘要:本发明涉及一种以泰乐菌素d为原料制备替米考星的方法,该方法以泰乐菌素d为原料,通过选择性氧化剂将20位伯羟基氧化为醛基得到中间体1,再水解脱碳霉糖得到中间体2,通过甲酸与3,5二甲基哌啶还原氨化反应得到产品替米考星.本发明以泰乐菌素d为原料,通过特定的选择性氧化剂使泰乐菌素d转变为合成替米考星的有效成分,避免转变为杂质,为替米考星的制备开辟了一条新途径,解决了现有以泰乐菌素为起始原料制备替米考星的杂质残留高与收率偏低的问题.

专利信息

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-2023399688-A1
优先权日:2015-08-20
标 题 :Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them
发明人：CULLER STEPHANIE; CHEN IHSIUNG BRANDON; PHARKYA PRITI; VAN DIEN STEVE; BARTON NELSON
权利人:GENOMATICA INC
摘要:In alternative embodiments, provided herein are transcription/translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.

专利号:US-7507380-B2
优先权日:2004-03-19
标 题 :Microchemical nanofactories
发明人：CHANG CHIH-HUNG; PAUL BRIAN KEVIN; REMCHO VINCENT THOMAS
权利人:OREGON STATE
摘要:Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one valve, and often plural, selectively actuatable valves. Detectors, including optical detectors, also can be used to detect product and other materials as they flow by, or are otherwise presented to, the detector. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. The apparatus is particularly useful for making compounds requiring iterative reaction schemes, and further can be used to make compounds having morphological structures that resemble the morphology of the apparatus itself, such as dendrimers.

专利号:US-2012298037-A1
优先权日:2006-09-01
标 题:Microchemical nanofactories
发明人：PAUL BRIAN KEVIN; CHANG CHIH-HUNG; REMCHO VINCENT THOMAS
权利人:PAUL BRIAN KEVIN; CHANG CHIH-HUNG; REMCHO VINCENT THOMAS; STATE UNIVERSITY; OREGON STATE
摘要:Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.

专利号:WO-2024254278-A9
优先权日:2023-06-08
标题 :Ophthalmic films
发明人：BANERJEE AMRITA; MITRAGOTRI SAMIR; LEVINSON DOUGLAS
权利人:FOUNT BIO INC
摘要:The present application describes the synthesis, formulation and uses of systems comprising conjugates or materials prepared therefrom, capable of retaining systems on the ocular surface.

专利号:CN-105254693-A
优先权日:2015-11-13
标题 :A new synthesis method of tedrol