CAS: 104617-86-9; N6-Propyl-4,5,6,7-Tetrahydrobenzo[d]Thiazole-2,6-Diamine

上下游产品

propionaldehyde 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole 2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole N,N-4-ox°Cyclohexyl-n-propyl-amine (R)-(+)-pramipexole pramipexole N6-(2-(4-(4′-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine N6-(2-(4-(3′-methoxybiphenyl-4-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

📜2-Amino-6-N-Propylamino-5,6,7,8-Tetrahydrobenzthiazole Dihydroiodide Salt置于sodium Hydroxide体系中,用 水 用作溶剂,化学反应 1.25H,以75.5%的收率获得(+/-)-普拉克索
参考文献: Process For The Preparation Of 2-Amino-4,5,6,7-Tetrahydro-6-Aminobenzothiaoles From Cyclohexanes And Cyclohexanones As Intermediates[fr] Procede De Preparation De 2-Amino-4,5,6,7-Tetrahydro-6-Aminobenzothiaoles A Partir De Cyclohexanes Et De Cyclohexanones En Tant Qu'Intermediaires
标题: Process For The Preparation Of 2-Amino-4,5,6,7-Tetrahydro-6-Aminobenzothiaoles From Cyclohexanes And Cyclohexanones As Intermediates[fr] Procede De Preparation De 2-Amino-4,5,6,7-Tetrahydro-6-Aminobenzothiaoles A Partir De Cyclohexanes Et De Cyclohexanones En Tant Qu'Intermediaires
摘要:本发明涉及从环己烷(2A)和环己酮(3A)中间体制备2-氨基-4,5,6,7-四氢-6-氨基苯并噻唑(5A)的过程.

专利信息

专利号:US-9512096-B2
优先权日:2011-12-22
标题 :Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
发明人：CHEN WEIRONG; HUMORA MICHAEL; KWOK DAW-LONG ALBERT; KIESMAN WILLIAM F; IRDAM ERWIN AYANDRA
权利人:KNOPP BIOSCIENCES LLC; KNOPP BIOSCIENCES LLP
摘要:The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-7662610-B2
优先权日:2006-01-13
标 题:Synthesis of intermediates for the preparation of pramipexol
发明人：RIVA SERGIO; FASSI PAOLA; SCARPELLINI MICHELE; ALLEGRINI PIETRO; RAZZETTI GABRIELE
权利人:DIPHARMA FRANCIS SRL
摘要:A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof n nwherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof,n n nwherein R 1 is straight or branched C 1 -C 6 alkyl, optionally substituted with phenyl; (the asterisk * and R defined above), with a lipase from Candida antarctica , under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.

专利号:US-8519148-B2
优先权日:2007-03-14
标题 :Synthesis of chirally purified substituted benzothiazole diamines
发明人：RAJE PRASAD; GADIKOTA RAJENDRAKUMAR REDDY; CHEN JIAN-XIE; LAPINA OLGA V; MCCALL JOHN M
权利人:RAJE PRASAD; GADIKOTA RAJENDRAKUMAR REDDY; CHEN JIAN-XIE; LAPINA OLGA V; MCCALL JOHN M; KNOPP NEUROSCIENCES INC
摘要:Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.

专利号:US-2013079526-A1
优先权日:2010-03-03
标题:Synthesis of Chirally Purified Substituted Benzothiazole Diamines
发明人：GREENFIELD SCOTT JEFFREY; GIBB CAMERON SEATH; GADIKOTA RAJENDRA KUMAR REDDY
权利人:GREENFIELD SCOTT JEFFREY; GIBB CAMERON SEATH; GADIKOTA RAJENDRA KUMAR REDDY; KNOPP NEUROSCIENCES INC
摘要:Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro- 6 -(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.

专利号:WO-2009035652-A1
优先权日:2007-09-13
标 题 :Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof