📜2-氧化吲哚-4-甲酸甲酯置于platinum(Iv) Oxide 氢气体系中,用 乙醇 用作溶剂,以90%的收率获得2,3-乙二氧基酚 参考文献:Utilisation Du Groupement Cyanométhyle Comme Motif Protecteur Des Phénols,Amines Et Carbamates 标题:Utilisation Du Groupement Cyanométhyle Comme Motif Protecteur Des Phénols,Amines Et Carbamates 摘要:The Use Of The Cyanomethyl Unit As A Protecting Group For Phenols,Primary And Secondary Amines,And Carbamates Is Described. Optimized Conditions For Formation And Hydrolysis Of Cyanomethyl In The Presence Of The Other Hydrogenolysis-Sensitive Groups Such As O-And N-Benzyl Groups Are Presented. Doi:10.1016/s0040-4039(00)60401-X
专利号:US-2003040639-A1 优先权日:1999-12-30 标题:Method for the preparation of substituted benzene derivatives 发明人:RUHLAND THOMAS; ROTTLANDER MARIO; ANDERSEN KIM 权利人:LUNDBECK & CO AS H 摘要:A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.
专利号:WO-0149681-A1 优先权日:1999-12-30 标题 :A method for the preparation of substituted benzene derivatives 发明人:RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM 权利人:LUNDBECK & CO AS H; RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM 摘要:A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.
参考文献:10.1007/978-1-0716-2152-3_13 摘要:Gärtner A, de Almeida Santos G, Ruff AJ, Schwaneberg U. A Screening Method for P450 BM3 Mutant Libraries Using Multiplexed Capillary Electrophoresis for Detection of Enzymatically Converted Compounds. Methods Mol Biol. 2022;2461():195–210. doi: 10.1007/978-1-0716-2152-3_13.