CAS: 100-73-2; 3,4-Dihydro-2H-Pyran-2-Carbaldehyde

上下游产品

acrolein 2-hydroxymethyl-3,4-dihydro-2H-pyran -butyl vinyl ether acrylic acid methyl ester H-pyran-2-yl)-acetonitrilebenzoyloxy-(3,4-dihydro-2H-pyran-2-yl)-acetonitrile -methanolopt.-inakt. Phenyl-3,4-dihydro-2H-pyranyl-(2)-methanol H-pyran-2-carbaldehyde-methallylimine3,4-dihydro-2H-pyran-2-carbaldehyde-methallylimine Tetrahydropyran-2-methanol

丙烯醛 反应 3.0H,以68%的收率获得3,4-二氢-2H-吡喃-2-甲醛
参考文献:通过顺序不对称 Horner-Wadsworth-Emmons 和钯催化的烯丙基取代反应的对映收敛合成
标题:通过顺序不对称 Horner-Wadsworth-Emmons 和钯催化的烯丙基取代反应的对映收敛合成
摘要:已经开发了一种对映聚合合成的新方法.该策略依赖于不对称 Horner-Wadsworth-Emmons (Hwe) 反应和钯催化烯丙基取代的组合.不同的 α-氧取代的外消旋醛最初通过不对称 Hwe 反应转化为两种主要的 α,β-不饱和酯的混合物,它们的烯丙基立体中心具有相反的构型以及相反的烯烃几何形状.随后,这些烯烃的异构混合物可以与碳,氮和氧亲核试剂进行钯催化的烯丙基取代反应.在后一步中,观测到各自的 (E) 和 (Z) 烯烃底物异构体以相反的立体定向反应:(E) 烯烃与保留反应,(Z) 烯烃与烯丙基立体中心和烯烃几何结构的立体化学反转.因此,以高异构体纯度获得作为总产物的单一γ-取代酯.该方法被应用于 Iejimalides 亚基的合成,Iejimalides 是一组细胞毒性大环内酯类.
Doi:10.1021/ja005809Q

专利信息

专利号:US-4080334-A
优先权日:1968-11-22
标题:Intermediates in the total synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-3985771-A
优先权日:1968-11-22
标题:Total steroid synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-nor-steroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 13β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-4044004-A
优先权日:1968-11-22
标题 :Total steroid synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereospecific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-5189184-A
优先权日:1990-08-30
标题:2-(3'-butenyl)-3,4-dihydro-2h-pyrans, their synthesis and use
发明人：SCHAEFER DIETMAR; WEIER ANDREAS; WEITEMEYER CHRISTIAN; WEWERS DIETMAR
权利人:GOLDSCHMIDT AG TH
摘要:2-(3'-butenyl)-3,4-dihydro-2H-pyrans of the general formula wherein R is a hydrogen group or an alkyl group with 1 to 6 carbon atoms. Methods for the synthesis of these compounds and their use as reactive modifiers or diluents for cationically curable monomers or polymers.

专利号:US-3984427-A
优先权日:1968-11-22
标 题:Preparation of vinyl lactones and corresponding Mannich bases
发明人：SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:Vinyl ketones and Mannich-bases obtained therefrom are useful as intermediates in the total synthesis of steroids having valuable pharmacological properties. These compounds are prepared by the low temperature reaction of a vinyl Grignard e.g., vinyl magnesium chloride with substituted γ, δ or ε lactones followed, if desired, by reaction of the vinyl ketone obtained with a primary or secondary amine. Particular compounds prepared by this procedure include 2-(2-substituted aminoethyl)-6-substituted-2-hydroxy-tetrahydropyrans and the tautomers thereof.

专利号:US-3838163-A
优先权日:1968-11-22
标题 :Substituted isoxazole derivatives as steroid intermediates
发明人：SAUCY G; SCOTT J
权利人:HOFFMANN LA ROCHE
摘要:THE NOVEL INTERMEDICATES AND PROCESSES OF THIS INVENTION PROVIDES A NEW SYNTHETIC ROUTE FOR THE PREPARATION OF PHARMACEUTICALLY VALUABLE19-NOR-STEROIDS. FURTHER, THE INTERMEDICATES AND PROCESSES OF THE INVENTION PROVIDE A NOVEL ROUTE FOR THE PREPARATION OF PHARMACEUTICALLY VALUABLE ESTRONES. THE PRESENT INVENTION PROVIDES A FACILE TOTAL SYNTHESIS OF 13B-ALKYL-C D-TRANS-STEROIDAL MATERIALS. THE DESIRABLE RESULT IS OBTAINED VIA A UNIQUE ASYMMETRIC INDUCTION FOLLOWED BY SUBSEQUENT STEREO-SPECIFIC REACTION STEPS. AS APRECURSOR TO THE SUBSEQUENT STEREOIDAL RING A, A 3,5-DISUBSTI 4-ISOXAZOLYLMETHYLENE GROUO IS EMPLOYED IN THIS SYNTHESIS.