CAS: 69004-03-1; 1-Methyl-3-(3-Methyl-4-(4-((Trifluoromethyl)Thio)Phenoxy)Phenyl)-1,3,5-Triazinane-2,4,6-Trione

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CAS号106310-17-2 1-methyl-5-[3-m... | CAS号105-58-8 碳酸二乙酯 | CAS号106310-18-3 3-methyl-5-[3-m...

1-Methyl-3-[3-Methyl-4-(4-Trifluoromethylthiophenoxy)Phenyl]Urea置于sodium Methylate,溶剂黄146体系中,用 N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 15.33H,反应生成 托曲珠利
参考文献:一种合成动物用抗球虫药物妥曲珠利的方法
标题:一种合成动物用抗球虫药物妥曲珠利的方法
摘要:本发明公开了一种抗球虫药物妥曲珠利的合成方法,所述的方法为:将3‑甲基‑4‑(4‑三氟甲硫基‑苯氧基)‑苯胺与甲氨基甲酰氯混合,在有机溶剂a中,在30~100oc下反应1~6H,待反应完全,得到反应液a经后处理,得到1‑甲基‑3‑[3‑甲基‑4‑(4‑三氟甲硫基‑苯氧基)‑苯基]‑脲粗品溶于有机溶剂b中,在0~40oc下,加入无机酸,反应1~5H,再加入氰酸盐水溶液,在35~50oc下,保温反应2~12H,得到反应液b经后处理得3‑甲基‑1‑[3‑甲基‑4‑(4‑三氟甲硫基苯氧基)苯基]‑缩二脲;将碳酸二乙酯和碱性物质混合,在40~80oc下加入3‑甲基‑1‑[3‑甲基‑4‑(4‑三氟甲硫基苯氧基)苯基]‑缩二脲,在有机溶剂c中,保温反应2~8H,得到反应液c经后处理得妥曲珠利纯品.本发明采用价廉易得的原料,反应条件温和,更环保,安全.

专利信息

专利号:CN-111087385-A
优先权日:2019-09-03
标题:Method for the selective synthesis of benzyl trifluoromethyl sulfide

专利号:CN-101265236-B
优先权日:2008-04-28
标 题:Synthesis of Toltrazuril

专利号:US-6861523-B2
优先权日:2002-02-08
标 题 :1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
发明人：YU YONGPING; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.

专利号:CN-111087385-B
优先权日:2019-09-03
标题:Method for the selective synthesis of benzyl trifluoromethyl sulfide

专利号:CN-117510426-A
优先权日:2024-01-04
标题 :A kind of synthesis method of anti-coccidial veterinary drug triazine ring

专利号:WO-2024254278-A9
优先权日:2023-06-08
标题 :Ophthalmic films
发明人：BANERJEE AMRITA; MITRAGOTRI SAMIR; LEVINSON DOUGLAS
权利人:FOUNT BIO INC
摘要:The present application describes the synthesis, formulation and uses of systems comprising conjugates or materials prepared therefrom, capable of retaining systems on the ocular surface.