专利号:US-9573932-B2 优先权日:2015-03-02 标题:Synthesis of intermediates in the preparation of ALK inhibitor 发明人:XU YONG 权利人:XU YONG 摘要:The present disclosure provides a method for preparing a compound of formula XVII, comprising: (1) contacting a compound of formula XIV with a compound of formula 3 to obtain a compound of formula 2; and (2) contacting the compound of formula 2 with a compound of formula 4 to obtain a compound of formula XVII. The method is low toxicity, cheap, easy to get, environmentally and friendly, and is economical and industrially applicable.
专利号:US-8952207-B2 优先权日:2007-09-11 标题:Copper-catalyzed C—H bond arylation 发明人:DAUGULIS OLAFS; DO HIEN-QUANG 权利人:DAUGULIS OLAFS; DO HIEN-QUANG; UNIV HOUSTON SYSTEM 摘要:The present invention is a one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using a combination of aryl halides, a substrate, and a copper salt as catalyst. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores and explosives.
专利号:US-2016257667-A1 优先权日:2015-03-02 标 题:Synthesis of intermediates in the preparation of alk inhibitor
专利号:CN-110128295-A 优先权日:2019-05-16 标 题 :A kind of production technology based on microreaction synthesis of 2-chloro-5-nitrobenzonitrile
[参考文献]: A P Kumar, Et Al. Vibrational Analysis Of Substituted Benzonitriles. Iii. Transferability Of Force Constants--The Case Of Some Halogeno-, Methoxy- And Nitro-Benzonitriles. Spectrochim Acta A Mol Biomol Spectrosc. 1997 Oct 15;53A(12):2041-8. [参考文献]: Beixi Wang, Et Al. Matrix-Assisted Ionization Vacuum For High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometers. Anal Chem. 2014 Jul 15;86(14):6792-6. [参考文献]: Ellen D Inutan, Et Al. Matrix Assisted Ionization Vacuum (Maiv), A New Ionization Method For Biological Materials Analysis Using Mass Spectrometry. Mol Cell Proteomics. 2013 Mar;12(3):792-6. [参考文献]: Nicholas D Chubatyi, Et Al. Improving The Sensitivity Of Matrix-Assisted Ionization (Mai) Mass Spectrometry Using Ammonium Salts. J Am Soc Mass Spectrom. 2015 Oct;26(10):1649-56. [参考文献]: Rachel R Ogorzalek Loo, Et Al. What Protein Charging (And Supercharging) Reveal About The Mechanism Of Electrospray Ionization. J Am Soc Mass Spectrom. 2014 Oct;25(10):1675-93.
合成参考文献
摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 388. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 361. 摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 371. 摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 132. 摘要:Ouali, A.; Taillefer, M., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 121.