CAS: 51-24-1; 2-(4-(4-Hydroxy-3-Iodophenoxy)-3,5-Diiodophenyl)Acetic Acid

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CAS号1155-40-4 3,5-二碘-THYRO乙酸 | CAS号85828-82-6 ethyl 3,5-diiod...

乙基[3,5-二碘-4-(4-甲氧基苯氧基)苯基]乙酸酯置于磷化氢,氨,氢碘酸,溶剂黄146体系中,化学反应生成 替拉曲考
参考文献:Obstetric Anesthesia Practice In Canada
标题:Obstetric Anesthesia Practice In Canada
摘要:Purpose: To Describe Obstetric Anesthesia In Canada As Practiced In 1997: To Identify Practices At Variance With The Literature And The Opinions Of Experts: And To Identify Questions For Future Research.Methods: In 1997,A Detailed Postal Questionnaire Asking About The Practice Of Obstetric Anesthesia Was Mailed To All 1,539 Specialist Anesthesiologist Members Of The Canadian Anaesthetists' Society Residing In Canada. Nonresponders Were Mailed A Second Questionnaire Three Months Later.Results: There Were 865 Completed Questionnaires Returned For Analysis (56.2%). Of These,522 Anesthesiologists Practiced Obstetric Anesthesia (60.3%). The Data Were Subdivided Into Those From Anesthesiologists With A Full Or Part-Time University Based Practice (40.1%) And Those From A Community Based Practice (59.9%). University Based And Community-Based Anesthesiologists Have Very Similar Patterns Of Practice. Specific Areas Where Anesthesia Practice Was Different From Current Recommendations Included: (1) Information Provided When Obtaining Consent For Labour Epidural Analgesia,(2) Use Of Opioids And Local Anesthetics For Initiation Of Epidural Analgesia,(3) Use Of Coagulation Testing In Preeclampsia,(4) The Common Use Of Cutting Spinal Needles,(5) Use Of Neuraxial Morphine And Nonsteroidal Anti-Inflammatory Agents After Cesarean Deliveries,(6) Optimal Treatment Of Neuraxial Opioid Side Effects,(7) When To Insert An Endotracheal Tube For General Anesthesia After Delivery,And (8) Withdrawing Epidural Catheters Through Epidural Needles.Conclusions: This Survey Presents Reference Data On The Practice Of Obstetric Anesthesia In Canada In 1997. Anesthesiologists With University Affiliation Have Very Similar Practices To Those Without University Affiliations.
DOI:10.1007/bf03019874

专利信息

专利号:US-8420850-B2
优先权日:2010-05-14
标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
发明人：DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

专利号:US-10413555-B2
优先权日:2014-11-25
标题:Treatment of skin atrophy with a combination of triiodothyroacetic acid (TRIAC) and dehydroepiandrosterone (DHEA)
发明人：FAERGEMANN JAN; JOHANNSSON GUDMUNDUR; OHLSSON CLAES; BATCHELLER DEREK GREGORY; JOHNSSON JÖRGEN; TÖRNELL JAN
权利人:TROPHEA DEV AB
摘要:The aim of the present study was to investigate the effect of a combination of triiodothyroacetic acid (TRIAC) and dehydroepiandrosterone (DHEA) compared with TRIAC, DHEA or placebo alone on corticosteroid induced effect on collagen synthesis in humans. Six healthy male human volunteers aged 40-65 participated. Four areas of abdominal skin were pre-treated for 3 weeks with betamethasone valerate cream. The same areas were then treated with one of the following alternatives in the same cream vehicle: TRIAC, DHEA, TRIAC+DHEA and placebo for 2 weeks. Then suction blisters were raised in each of these areas with a vacuum pump. The blister fluid from each area was collected and frozen until analysis. Analysis of amino terminal propeptide of human type I procollagen (PINP) in suction blister fluid was performed using a commercially available immunoassay (Orion Diagnostics) kit. This study has for the first time shown that a combination of TRIAC and DHEA could effectively stimulate collagen synthesis in skin pretreated with betamethasone valerate demonstrated by an increase in PINP, and that the combination was more effective than TRIAC or DHEA alone. This combination could be used to effectively treat skin atrophy in corticosteroid induced skin atrophy. It could also be used to treat skin atrophy due to other circumstances such as e. g. sun damaged skin and skin atrophy due to high age. Another interesting application would be to combine TRIAC and DHEA with a potent corticosteroid in order to prevent corticosteroid induced skin atrophy. If this combination still is effective in the treatment of eczema and psoriasis and without the risk of skin atrophy this combination will be a major breakthrough for the use of potent topical corticosteroids.

专利号:US-11186551-B2
优先权日:2020-04-29
标题 :Composition of scalable thyrointegrin antagonists with improved retention in tumors
发明人：MOUSA SHAKER A; HAY BRUCE A
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compounds/compositions, methods of synthesis, and methods of use. The compounds/compositions are directed toward thyrointegrin antagonists conjugated to a polymer. The compounds/compositions further comprise an additional substituent also conjugated to the polymer. The compounds/compositions demonstrate increased uptake across the blood brain barrier along with increased retention therein and retention within tumor. The compounds/compositions may also include improved synthesis scalability, improved purity, improved aqueous solubility, and a solid product or intermediate. The compounds/compositions may demonstrate improved antiangiogenic effect and improved efficacy against conditions, particularly cancers, requiring blood brain barrier permeability, for example, glioblastoma (GBM).

专利号:WO-2022260918-A1
优先权日:2021-06-07
标 题:Composition and method for dual targeting in treatment of neuroendocrine tumors
发明人：MOUSA SHAKER; RAJABI MEHDI; KARAKUS OZLEM O
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone ανβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.

专利号:US-4405219-A
优先权日:1980-03-17
标 题 :Optical image synthesis method and apparatus
发明人：YASUDA MITSUO; MINAMI KATSUJI; ITOKAWA JIRO; AOTO YOSHIYUKI; HATAKEYAMA YASUYUKI; SAKAIDA SHINYA
权利人:SHARP KK
摘要:In one aspect of the present invention, an optical image synthesizer is adapted such that there is provided a partial mirror at the junction of two projecting axes with an angle of 45° with respect to these optical axes for the purpose of projecting a composite image onto a screen. By selectively moving the partial mirror about its rotation axis into the above-mentioned angular position and out of one of the projection ranges, composed images and pre-composed are respectively projected onto the screen. Preferably, the distance between the principal points of respective lenses and the screen are equal to each other within an optical system including the lenses, the mirror and the screen. A source of illuminating light for photographs is focused by means of a cylindrical lens. Means are provided for moving the level of the partial mirror along its height. A microswitch is disposed to sense a photograph holder inserted and energize the illumination lamp only when the holder is sensed. Moreover, it is preferable that a shutter be disposed at an optical path between the mirror and the illumination light source to hide an undesirable image from view. The photographs are made slidable in a vertical direction by use of an adjusting device. When composing a combination of a new coiffure and the face of a customer is desirable, the optical axis of a zoom lens is fixed at the eye-to-eye center of the customer to eliminate any definite boundary therebetween. Preferably, markings indicative of the level of eyes and the center of faces are formed at a facelike aperture in the photograph holder.

专利号:US-11077082-B2
优先权日:2018-04-11
标题 :Composition and method for dual targeting in treatment of neuroendocrine tumors
发明人：MOUSA SHAKER; RAJABI MEHDI; KARAKUS OZLEM O
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.