CAS: 4890-85-1; 2-Phenethylbenzoic Acid

上下游产品

CAS号869070-21-3 2-[2-(3-bromo-p... | CAS号5079-90-3 Benzoic acid,2-... | CAS号575-61-1 3-亚苄基酞 | CAS号124-38-9 二氧化碳 | CAS号103-29-7 1, 2-二苯乙烷 | CAS号60901-21-5 2-styrylbenzoic acid | CAS号38453-72-4 methyl 2-[(E)-2... | CAS号60494-73-7 Phosphonium,[[2... | CAS号833-48-7 10,11-二氢-5H-二苯并... | CAS号835-78-9 2-苯乙基苯甲醇 | CAS号1210-33-9 二苯并环庚烯酮基氯 | CAS号1210-34-0 5-羟基-10,11-二氢-5... | CAS号1210-35-1 二苯并环庚酮 | CAS号32832-96-5 2-苯乙基苯甲醛 | CAS号2222-33-5 5-二苯并环庚烯酮 | CAS号36795-27-4 BENZOYL CHLORID... | CAS号256-81-5 二苯并环庚烯 | CAS号22253-11-8 2-phenyl-2,3-di...

📜3-苄基氯苯酞置于palladium On Activated Carbon,W(Otf)6,氢气体系中,用 溶剂黄146 作为反应溶剂,50.0 °C,101.33 Kpa 条件下,反应 12.0H,以86%的收率获得产物2-苯乙基苯甲酸
参考文献:金属三氟甲磺酸酯促进内酯氢解成羧酸的综合研究:从合成和机理的角度
标题:金属三氟甲磺酸酯促进内酯氢解成羧酸的综合研究:从合成和机理的角度
摘要:内酯直接氢解为羧酸(即不接触羰基的c烷氧基-O键的氢解)通常是困难的,因为当前使用布朗斯台德酸作为催化剂的策略通常需要苛刻的条件,例如高温和高温h 2压力.在此,我们报告了已开发的无溶剂催化转化方法,其中w(otf)6被认为可以促进氢解过程.该策略可以在特别温和的条件下(例如,反应温度<150oc和1 Atm H 2的条件下)有效地将内酯氢化为羧酸),并显示出较宽的基材范围.另外,该催化方案可以进一步应用于作为可再生聚合物的聚羟基链烷酸酯的氢解成相应的直链羧酸.随后进行了广泛的机理研究,密度泛函理论计算揭示了一种反应模式,包括在w(otf)6的帮助下c═o键的完全裂解催化剂.此外,通过电喷雾电离质谱已成功检测到该机理中产生的关键中间体,即具有otf部分的moiety.通过与布朗斯台德酸催化体系的比较,研究证实了otf部分的存在可以显着降低与重排和消除过程相关的障碍.同时,重点放在阴离子发挥
DOI:10.1021/acscatal.7B01569

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:WO-9617589-A1
优先权日:1994-12-08
标 题 :Method of smoothing or removing wrinkles and method of stimulating collagen synthesis
发明人：FUJIMURA TSUTOMU; OGAWA AYUMI; OHSU HIROYUKI; TAKEMA YOSHINORI; HORI KIMIHIKO; AMANO SHINYA; FUJIMORI TAKETOSHI; OHASHI YUKIHIRO; SUZUKI YASUTO
权利人:KAO CORP; FUJIMURA TSUTOMU; OGAWA AYUMI; OHSU HIROYUKI; TAKEMA YOSHINORI; HORI KIMIHIKO; AMANO SHINYA; FUJIMORI TAKETOSHI; OHASHI YUKIHIRO; SUZUKI YASUTO
摘要:The present invention relates to methods of stimulating collagen synthesis and of smoothing or removing wrinkles, which comprise administering an effective amount of a benzoic acid derivative of formula (1) or a salt thereof, wherein X is -O- or -N(R4)- (R4 is H or the like), R1 is a C¿4-25?-alkyl or C4-25-alkenyl group, R?2¿ is H, OH, or a C¿1-6?-alkoxyl or C1-6-alkanoyloxy group, and R?3 is -OR5¿ or -N(R?6)R7 (R5? is H, or a C1-25-alkyl or C1-25-alkenyl group), and R?6 and R7¿ are individually H, or a C¿1-3?-alkyl or C1-3-alkenyl group, and use of this compound for agents for stimulating synthesis of collagen, and smoothing or removing wrinkles. This compound (1) stimulates collagen synthesis in human dermal fibroblasts and consequently smooths or removes wrinkles caused by aging and/or photoaging.

专利号:WO-2008151306-A1
优先权日:2007-06-05
标题 :Synthesis of cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity
发明人：PETTIT GEORGE R; SMITH THOMAS H; FENG SONG
权利人:UNIV ARIZONA; PETTIT GEORGE R; SMITH THOMAS H; FENG SONG
摘要:The present invention is directed to effective methods of synthesizing cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity. Total syntheses of the eighteen-membered ring cyclodepsipeptides kitastatin (1a) and respirantin (1b) are taught. One important step in the synthesis is an intramolecular transesterification of the ?-ketoester alcohol 6 to afford the protected macrocycle 5. The synthetic products were shown to be identical to the natural products and the absolute stereochemistry of 6 of the 7 asymmetric centers of cyclodepsipeptide 1b was unequivocally established. Kitastatin (1a) and respirantin (1b) were found to be remarkable inhibitors of cancer cell growth and are related to the antimycin family of antibiotics.

专利号:US-3839363-A
优先权日:1972-04-25
标 题:Synthesis of zearalanone and related compounds and intermediates useful in the synthesis thereof
发明人：SHAH D; HURD R
权利人:COMMERCIAL SOLVENTS CORP
摘要:1. A COMPOUND OF THE FORMULA 1-(O=),3-(C6H5-CH2-O-(CH2)N0-),4-(CH3-OOC-),- 6,8-DI(R''-O-)ISOCHROMAN WHEREIN NO IS AN INTEGER HAVING THE VALUE 1,2,3,4,5 OR 6 AND R'' IS SELECTED FROM THE GROUP CONSISTING OF BENZYL, METHYL, ETHYL, BUTYL, CYCLOPENTYL, AND CYCLOHEXYL.

专利号:US-2024417358-A1
优先权日:2021-10-04
标题:Continuous Flow Reactor and Process for Synthesis of Substituted Benzoic Acid
发明人：JOSHI SUNIL SHANKAR; MALI NILESH ATMARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a non-hazardous, improved continuous oxidation process for the preparation of substituted benzoic acid of formula (I) by using continuous process reactor system with improved process controls. (I) wherein: R 1 is H, F, Cl, Br, I, NO 2 , amine, or C 1 -C 5 alkyl; R 2 is H, F, Cl, Br, I, NO 2 , amine, or C 1 -C 5 alkyl; and R 3 is H, F, Cl, Br, I, NO 2 , amine, C 1 -C 5 alkyl;