CAS: 38689-31-5; (S)-2-((R)-2-Amino-4-Methylpentanamido)-4-Methylpentanoic Acid

相似化合物

3303-31-9 73401-65-7 88743-98-0

上下游产品

N-carbobenzyloxy leucine L-Leucine benzyl ester 2-(Benzyloxycarbonyl)-D-leucyl]-L-leucine[N2-(Benzyloxycarbonyl)-D-leucyl]-L-leucine Nα-Benzyloxycarbonyl-D-leucyl-L-leucine methyl esterL-leucyl-L-leucine L-leucyl-D-leucine

📜Nα-Benzyloxycarbonyl-D-Leucyl-L-Leucine Methyl Ester置于palladium On Activated Charcoal 氢气,溶剂黄146体系中,用 乙醇 作为反应溶剂,化学反应生成 D-亮氨酰-L-亮氨酸
参考文献:肽-xiii:构型对一些简单肽的介电增量和环化的影响
标题:肽-xiii:构型对一些简单肽的介电增量和环化的影响
摘要:非对映异构的缩水甘油基亮氨酰甘氨酰甘氨酸的环化,通过它们的对-硝基苯基巯基酯,或借助于二环己基碳二亚胺,产生39%的dl和12%的11环五肽.相应地,开链d1五肽的介电增量仅为ii的五分之一的64%,并且在几对非对映异构体二肽和三肽中发现了相似的差异.根据肽链的优选构象对这些结果进行了初步讨论.
DOI:10.1016/0040-4020(63)80009-5

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:WO-0018790-A1
优先权日:1998-09-25
标 题 :Synthesis of cyclic peptides

专利号:US-3753970-A
优先权日:1970-08-04
标题:Cyclopeptides derived from polymyxins and their preparation
发明人：BOUCHAUDON J; JOLLES G
权利人:RHONE POULENC SA
摘要:THE NEW CYCLOPEPTIDES OF THE FORMULA: DAB<(-DAB(-G)-Y-Z-DAB(-G)-DAB(-G)-THR-) IN WHICH Y-Z REPRESENTS AN AMINO ACID CHAIN SELECTED FROM D-LEU-THR,D-PHE-LEU, D-LEU-LEU AND D-LEU-ILEU, G REPRESENTS AN AMINO-PROTECTING RADICAL OF THE FORMULA: PY-CH(-R)-OOC- IN WHICH PY REPRESENTS PYRIDYL, PYRIDYL-N-OXIDE, OR PYRIDYL OR PYRIDYL-N-OXIDE CARRYING A METHYL SUBSTITUENT, R REPRESENTS HYDROGEN, ALKYL OF 1 TO THROUGH 5 CARBON ATOMS, OR PHENYL, AND DAB REPRESENTS A,Y-DIAMINOBUTYRIC AID, THE AMINO ACIDS HAVING THE L-CONFFIGURATION UNLESS OTHERWISE INDICATED, SAID CYCLOPEPTIDES CONTAINING ONLY A SINGLE FREE AMINO GROUP, ARE USEFUL INTERMEDIATES FOR THE SYNTHESIS OF SEMI-SYNTHETIC PRODUCTS DERIVED FROM POLYMYXINS.

专利号:AU-6183099-A
优先权日:1998-09-25
标 题:Synthesis of cyclic peptides

专利号:AU-766495-B2
优先权日:1998-09-25
标题:Synthesis of cyclic peptides

专利号:CA-2345407-A1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides