CAS: 20780-76-1; 5-Iodoindoline-2,3-Dione

上下游产品

CAS号91-56-5 靛红 | CAS号60313-92-0 p-iodoisonitros... | CAS号540-37-4 对碘苯胺 | CAS号302-17-0 水合氯醛 | CAS号7647-01-0 盐酸 | CAS号7790-99-0 一氯化碘 | CAS号64-19-7 冰醋酸 | CAS号7664-93-9 硫酸 | CAS号109496-98-2 5-苯基靛红 | CAS号1079-47-6 5-碘-1H-吲唑-3-羧酸甲酯 | CAS号443-69-6 5-氟靛红 | CAS号184905-10-0 5-iodo-1-(napht... | CAS号193354-13-1 5-碘吲哚啉-2-酮 | CAS号6374-92-1 5,7-二氯-1H-吲哚-2,3-二酮 | CAS号1077-97-0 5-碘-1H-吲哚唑-3-甲酸 | CAS号73818-16-3 N'-(5-iodo-2-ox... | CAS号433244-12-3 6-iodo-2-methyl...

靛红置于n-碘代糖精,Silica Gel体系中,用 二氯甲烷 用作溶剂,化学反应 8.0H,以80%的收率获得5-碘吲哚醌
参考文献:Sio2 介导的靛红与 N-卤代糖精的反应:5-卤代靛红的区域特异性制备
标题:Sio2 介导的靛红与 N-卤代糖精的反应:5-卤代靛红的区域特异性制备
摘要:7V-卤代糖精 (5 Mmol) 在室温下与靛红 (5 Mmol)置于sio2 (5 G) 存在下平稳反应反应生成5-卤代衍生物.使用该程序,以 48% 的纯化产率(72 小时)获得 5-溴靛红,58%(12 小时)的 5-溴靛红和 80%(8 小时)的 5-碘靛红.引言 表面介导的反应在有机合成中非常有用,在许多情况下,与溶液中的均质介质相比,产品的收率和选择性更高 (1).N-卤代琥珀酰亚胺被证明是在温和的均相或多相条件下卤化杂芳烃的有效试剂 (2).靛红 (L//-Indole-2,3-Dione,1) 是一种多功能分子,在合成有机化学中有许多应用 (3).此外,一些衍生物具有重要的生物学和药理学特性(3B).文献中描述了几种试剂 (4) 主要在 5 位进行靛红的卤化,其中包括 J-卤代酰胺和 N-卤代酰亚胺 (4A,4B).这些试剂是高毒性和腐蚀性的 Ci2 和 Br2 的合适
Doi:10.1515/hc.2003.9.1.31

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-2011263540-A1
优先权日:2008-07-25
标题 :Small-molecule inhibitors of protein synthesis inactivating toxins
发明人：PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.

专利号:US-2010087660-A1
优先权日:2002-12-20
标题 :Synthesis of amines and intermediates for the synthesis thereof

专利号:US-8710093-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof

专利号:CA-2508290-A1
优先权日:2002-12-20
标题:Synthesis of amines and intermediates for the synthesis thereof