CAS: 20776-67-4; 2-Amino-5-Chloro-3-Methylbenzoic Acid

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CAS号4389-45-1 2-氨基-3-甲基苯甲酸 | CAS号14389-06-1 5-氯-7-甲基靛红 | CAS号95-53-4 邻甲苯胺 | CAS号1132-03-2 2-(羟基亚氨基)-N-(2-... | CAS号1127-59-9 7-甲基靛红 | CAS号67-56-1 甲醇 | CAS号890707-28-5 2-氨基-5-氯-N,3-二甲基苯甲酰胺 | CAS号79101-83-0 2-氨基-5-氯-3-甲基苯甲酸甲酯

4-氨基-3,5-二氯苯甲酸置于硫酸,硝酸,Sodium Hydroxide,锌体系中,化学反应 3.0H,反应生成2-氨基-5-氯-3-甲基苯甲酸
参考文献:一种2-氨基-5-氯-N,3-二甲基苯甲酰胺的合成方法
标题:一种2-氨基-5-氯-N,3-二甲基苯甲酰胺的合成方法
摘要:本发明公开了一种2‑氨基‑5‑氯‑n,3‑二甲基苯甲酰胺的合成方法,属于有机化学合成技术领域.本发明是以甲苯为原料,首先在n‑羟基邻苯二甲酰亚胺和乙酰丙酮钴的催化下,氧化生成苯甲酸,然后与氯气发生取代反应生成3,5‑二氯苯甲酸,再用屏蔽试剂屏蔽掉5位氯,用格式试剂将3位氯发生甲基取代生成3‑甲基‑5‑氯苯甲酸,再在浓硫酸的催化下与硝酸发生硝基取代生成2‑硝基‑3‑甲基‑5‑氯苯甲酸,然后在催化加氢,将硝基还原成氨基,最后在n,N'‑二异丙基碳二亚胺与1‑羟基苯并三唑的作用下得到中间体,中间体与甲胺反应得到2‑氨基‑5‑氯‑n,3‑二甲基苯甲酰胺,本发明不仅操作简单,而且合成收率得到了显著的提高,提高到了92%以上.

专利信息

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:WO-2021033172-A1
优先权日:2019-08-20
标题:Process for the preparation of chlorantraniliprole
发明人：V ASHWIN; PRADHAN ASHOK KUMAR; PALIMKAR SANJAY SAMBHAJIRAO; MANE AVINASH SHESHRAO; KUNHIMON SYAM KUMAR UNNIARAN
权利人:EUROFINS ADVINUS LTD
摘要:The present invention relates to two novel, efficient and one-pot methods for synthesizing chlorantraniliprole. In the first scheme, Chlorantraniliprole is prepared by a novel telescopic process starting from 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid a key raw material-A (Key RM-A). In the second scheme, starting from Key RM-A, the process steps use of a novel variant of anthranilic acid (Methyl 2-amino-5-chloro-3-methylbenzoate), to get Chlorantraniliprole. Furthermore, the present invention also relates to the synthesis of key starting material for the synthesizing chlorantraniliprole in-situ. All the in-situ steps of the disclosed synthesis methods obtain good yield, without using any expensive reagent or base or harsh reaction conditions, which makes the process simple, environment friendly and more cost effective. With this process the production cost of chlorantraniliprole and its intermediates is substantially reduced; fewer by-products are formed during its synthesis and since it's a one-pot reaction, isolation and purification are easy to achieve.

专利号:EP-4217339-A1
优先权日:2020-09-26
标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof

专利号:TW-202222162-A
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof

专利号:CA-3191922-A1
优先权日:2020-09-26
标 题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof

专利号:IL-301294-A
优先权日:2020-09-26
标题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof