CAS: 19771-63-2; (R)-2-Oxothiazolidine-4-Carboxylic Acid

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875-97-8 19750-45-9 77273-78-0

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CAS号52-89-1 L-半胱氨酸盐酸盐(无水物) | CAS号1885-14-9 氯甲酸苯酯 | CAS号52-90-4 L-半胱氨酸 | CAS号32315-10-9 三光气 | CAS号75-44-5 光气 | CAS号127761-77-7 (R)-2-氧代噻唑烷-4-羧酸甲酯 | CAS号127761-77-7 (R)-2-氧代噻唑烷-4-羧酸甲酯

📜(R)-2-氧代噻唑烷-4-羧酸甲酯置于盐酸体系中,用 溶剂黄146 用作溶剂,化学反应生成丙半胱氨酸
参考文献:Total Synthesis Of (+)-Latrunculin A,An Ichthyotoxic Metabolite Of The Sponge Latrunculia Magnifica And Its C-15 Epimer
标题:Total Synthesis Of (+)-Latrunculin A,An Ichthyotoxic Metabolite Of The Sponge Latrunculia Magnifica And Its C-15 Epimer
摘要:Latrunculin A (1),An Ichthyotoxic Metabolite Of The Sponge Latrunculia Magnifica With Potent Inhibitory Action On Microfilament-Mediated Processes Involved In Cell Division,Was Synthesized Via A Convergent Approach. Construction Of A Major Segment Of The Latrunculin Backbone Was Accomplished By Means Of A Three-Component Coupling Of Aldehyde 24,Beta-Keto Ester 27,And Phosphonium Salt 26,Which Established The Conjugated Ez-Diene Moiety Of 31. The Thiazolidinone Subunit Of 1 Was Elaborated In The Form Of 39 From L-Cysteine And Was Linked To 35 Without Nitrogen Protection. Final Lactonization Of 47 Was Carried Out Using The Mitsunobu Protocol. A Parallel Sequence Employing The Epimeric Seco Acid 48 Produced 15-Epilatrunculin A.
Doi:10.1021/jo00046A008

专利信息

专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人：MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:US-11834468-B2
优先权日:2017-07-03
标 题:Protected tetrasaccharides, their process of preparation and their use as transglucosylase acceptor substrates in the chemo-enzymatic synthesis of Shigella flexneri specific oligosaccharides
发明人：MULARD LAURENCE; LE HEIGET GUILLAUME; HU ZHAOHU; BAREL LOUIS-ANTOINE; ANDRE ISABELLE; MOULIS CLAIRE; REMAUD-SIMEON MAGALI; BARBE SOPHIE; BENKOULOUCHE MOUNIR; BEN IMEDDOURENE AKLI
权利人:PASTEUR INSTITUT; AGRONOMIQUE INST NAT RECH; INSTITUT NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT
摘要:The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.

专利号:US-5208249-A
优先权日:1992-08-20
标 题 :Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate
发明人：ROWE W BRUCE; GOLDBERG DENNIS I
权利人:CLINTEC NUTRITION CO
摘要:A method for stimulating the intracellular synthesis of glutathione comprising the step of administering to a mammal a therapeutically effective amount of an ester of 2-oxothiazolidine-4-carboxylate is provided.

专利号:US-7662401-B2
优先权日:2002-04-08
标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase
发明人：MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.

专利号:US-6531608-B2
优先权日:1999-05-25
标题:Various thiol complexes, processes for their synthesis and clinical applications
发明人：PEARSON DON C; RICHARDSON KENNETH T
权利人:CHRONORX LLC
摘要:This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these and other related individual or complexed thiol-contributing glutathione predecessors. Clinical uses for these molecules and complexes in the beneficial modification of various physiological conditions and functions associated with aging, chronic glaucoma, diabetes mellitus, insulin resistance, macular degeneration, neurodegenerative diseases and vasoconstriction are described in particular.

专利号:EP-0501641-A1
优先权日:1991-02-26
标 题 :L-2-oxothiazolidine-4-carboxylate and glutathion esters for the treatment of hepatic diseases
发明人：TRIMBO SUSAN; GOLDBERG DENNIS I
权利人:CLINTEC NUTRITION CO
摘要:The use of a composition that stimulates the intracellular synthesis of glutathione for providing a composition for treating hepatic disease is provided. In an embodiment, composition, that is administered to a patient having hepatic disease, includes a compound chosen from the group consisting of: L-2-oxothiazolidine-4-carboxylate; glutathione esters; and thiazolidine-4-carboxylate analogs, in an amount sufficient to stimulate intracellular glutathione synthesis. The compound can be administered parenterally or enterally.