CAS: 16948-16-6; Boc-N-Me-Ala-Oh

相似化合物

19914-38-6 13734-31-1 1142-20-7

上下游产品

L-N-B°C-Ala methyl iodide N-methylalanine tert-butyl dicarbonatedi-tert-butyl dicarbonateN-methylalanine α-(tert-butoxycarbonyl)-Nα-methyl-L-alaninehydroxamateO-benzyl Nα-(tert-butoxycarbonyl)-Nα-methyl-L-alaninehydroxamate α-(tert-butoxycarbonyl)-Nα-methyl-L-alaninehydroxamateO-benzyl N-methyl-Nα-(tert-butoxycarbonyl)-Nα-methyl-L-alaninehydroxamate N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

(4S)-N-Tert-Butyloxycarbonyl4-Methyl-1,3-Oxazolidin-5-One置于palladium On Activated Charcoal 氢气体系中,用 甲醇 用作溶剂,化学反应生成Boc-N-甲基-L-丙氨酸
参考文献:光学纯n-甲基-α-氨基酸的实用方法
标题:光学纯n-甲基-α-氨基酸的实用方法
摘要:通过无消旋方法开发了一种新的实用的n-甲基-α-氨基酸合成方法.该方法包括在氢气存在下,用氢对n-保护的恶唑烷酮进行还原性裂解,以定量收率得到标题化合物.
Doi:10.1016/s0040-4039(98)00111-7

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:US-7312343-B2
优先权日:2004-06-02
标 题:Synthesis of α-amino-β-alkoxy-carboxylic acid esters
发明人：SCHMID RUDOLF; ZUTTER ULRICH
权利人:HOFFMANN LA ROCHE
摘要:Compounds of formula I n nand a process for the preparation of such compounds are disclosed.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2023214577-A1
优先权日:2022-05-02
标 题 :Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:The present invention addresses the problem of a desired elongation reaction not progressing as a result of a 6-membered cyclic amidine skeleton structure and a diketopiperazine formed when removing an N-terminated protective group during peptide synthesis. The inventors have discovered that it is possible to solve said problem during peptide production by treating a peptide protected by an N-terminated amino group in a protective group having an Fmoc skeleton by using a base which has a pKa of 23 or higher in an acetonitrile of a conjugate acid in a specific solvent, and next, performing peptide chain elongation.

专利号:US-4374060-A
优先权日:1981-07-15
标题 :Process for the preparation of cyclic hexapeptide
发明人：NUTT RUTH F
权利人:MERCK & CO INC
摘要:There is disclosed a process for preparing a cyclic hexapeptide somatostatin analog, specifically cyclo (D-Trp-Lys-Val-Phe-N-Me-Ala-Tyr). The cyclic hexapeptide is synthesized in large quantities in a solution synthesis procedure. However, because of the unexpectedly rapid cyclization rate of this compound, conditions have been developed such that a much more concentrated solution, and thus smaller volumes of the reaction medium, may be employed than would be expected.

专利号:CA-2567914-A1
优先权日:2004-06-02
标 题 :Synthesis of amino-alkoxy-heptanoic alkyl ester