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2-氧代-3-甲基丁酸置于[ruthenium(II)(η6-1-Methyl-4-Isopropyl-Benzene)(Chloride)(μ-Chloride)]2 甲烷磺酸,氢气,三乙胺,4,4'-Bis(Diphenylphosphino)-2,2',5,5'-Tetramethyl-3,3'-Bithiophene体系中,用 乙醇,1,2-二氯乙烷,甲苯 用作溶剂,25.0 °C,620.53 Kpa 条件下,反应 26.0H,反应生成N-苄氧羰基-D-缬氨酸
参考文献:Asymmetric Hydrogenation Of N-Sulfonylated-α-Dehydroamino Acids: Toward The Synthesis Of An Anthrax Lethal Factor Inhibitor
标题:Asymmetric Hydrogenation Of N-Sulfonylated-α-Dehydroamino Acids: Toward The Synthesis Of An Anthrax Lethal Factor Inhibitor
摘要:[graphic]A Novel And Highly Enantioselective Ru-Catalyzed Hydrogenation Of N-Sulfonylated-Alpha-Dehydroamino Acids Has Been Discovered And Demonstrated In The Synthesis Of An Anthrax Lethal Factor Inhibitor (Lfi). Herein,This Methodology Is Used To Prepare N-Sulfonylated Amino Acids In Up To 98% Ee. This Unprecedented Hydrogenation Uses A Chiral Ru Catalyst Rather Than Rh As Typical For Acylated Dehydroamino Acids And Esters,And This Work Reports The First Asymmetric Hydrogenation Of A Tetrasubstituted Dehydroamino Acid Derivative Using A Ru Catalyst.
Doi:10.1021/ol050869S

专利信息

专利号:JP-2005529076-A
优先权日:2002-02-15
标题:Synthesis of quinazolinone

专利号:US-7161002-B2
优先权日:2002-02-15
标 题 :Syntheses of quinazolinones
发明人：BERGNES GUSTAVE; HA EDWARD; YIANNIKOUROUS GEORGE; KALARITIS PANOS; YONCE BRANDON E; WELDAY JR KURT ALAN
权利人:SMITHKLINE BEECHAM CORP
摘要:The present invention provides novel quinazolinone compositions of matter comprising enantiomerically pure compound represented by Formula I: n nor a pharmaceutically acceptable salt thereof, having a detectable amount of one or more starting material and/or reagent used in the synthesis thereof.

专利号:CA-2475879-A1
优先权日:2002-02-15
标 题 :Synthesis of quinazolinones