专利号:US-3959322-A 优先权日:1960-09-22 标 题:Synthesis of 13-alkyl-gon-4-ones 发明人:HUGHES GORDON ALAN; SMITH HERCHEL 权利人:SMITH HERCHEL 摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.
专利号:WO-0007607-A1 优先权日:1998-08-04 标 题:Nutrient and therapeutic compositions for the treatment of cancer 权利人:KOSBAB JOHN V 摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.
专利号:US-2836608-A 优先权日:1955-05-27 标 题 :Synthesis of steroids 发明人:JOSEF FRIED; THOMA RICHARD W; DAVID PERLMAN; GERKE JOHN R 权利人:OLIN MATHIESON
专利号:CA-2362719-A1 优先权日:1991-03-01 标 题:Synthesis of nicotinic analogs useful for the treatment of degenerative diseases of the nervous system
专利号:US-5602257-A 优先权日:1991-03-01 标 题:Synthesis of nicotinic analogs
专利号:RU-2190604-C1 优先权日:2001-09-17 标 题 :METHOD OF SYNTHESIS OF N-NICOTINOYL--γ-AMINO-BUTYRIC ACID
1: Menzel C, Silbernagl J, Laffleur F, Leichner C, Jelkmann M, Huck CW, Hussain S, Bernkop-Schnürch A. 2,2'Dithiodinicotinyl ligands: Key to more reactive thiomers. Int J Pharm. 2016 Apr 30;503(1-2):199-206. doi: 10.1016/j.ijpharm.2016.03.010. Epub 2016 Mar 10. doi: 10.1021/ol4025265. Epub 2013 Oct 4. doi: 10.1016/j.jcis.2013.04.039. Epub 2013 May 1. doi: 10.1016/j.ijbiomac.2011.11.006. Epub 2011 Nov 17. Italian. 20: Fleming I, Mason JB. A product from the reaction of pyridine with acetic anhydride. J Chem Soc Perkin 1. 1969;18:2509-10.
合成参考文献
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