CAS: 141474-37-5; 2,4-Dibromo-6-Fluoroaniline

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65896-11-9 367-24-8 444-14-4

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CAS号348-54-9 邻氟苯胺

2-氟苯胺置于benzyltrimethylammonium Tribromide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 1.0H,以89%的收率获得2,4-二溴-6-氟苯胺
参考文献:Epr研究以氮为中心的自由基.第53部分:N-(芳硫基)-2,4-二芳基-6-氰基苯基氨基的分离,Epr光谱和磁特性
标题:Epr研究以氮为中心的自由基.第53部分:N-(芳硫基)-2,4-二芳基-6-氰基苯基氨基的分离,Epr光谱和磁特性
摘要:N-(芳硫基)-2,4-二芳基-6-乙氧基羰基苯基氨基(1),N-[(2,4-二氯苯基)硫基]-2,4-二苯基-6-乙酰基苯基氨基(2),N-(芳硫基)-2,4-二芳基-6-氰基苯基氨基(3),N-[(2,4-二氯苯基)硫基]-2,4-双(4-氯苯基)-6-氟苯基氨基(4)和n-[(4-硝基苯基)硫基]-2,4-二苯基苯基氨基(5)是通过氧化作用相应的n-(芳硫基)苯胺中的一个.虽然4和5分别短命和在30分钟内衰减,1-3是相当持久的和3可以分离作为自由基晶体. Epr光谱测量产生的所有自由基的自由基并评估自旋密度分布.进行了从头算mo的计算(uhf Becke 3Lyp / Sto 6-31G),并对自旋密度分布进行了定量讨论.对三个分离的自由基进行了磁化率测量,Squid磁力计.发现一个自由基与铁磁耦合,并且使用一维规则海森堡模型进行分析得出2 J / K B =
Doi:10.1039/b100276G

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.